DegronMD

Uniprot ID: Q6WRI0

Source protein: Immunoglobulin superfamily member 10

Source gene: IGSF10

Class: DEG_SCF_TRCP1_1

Location: 2088:2093

E3 ligase: BTRC

DEGRON score: 0.7994

ASA_SCORE: 81.75

COIL: 0.7723

CONS_SCORE: 0.4106

DSS_SCORE: 0.385

HELIX: 0.059

FCONS_SCORE: 0.8295

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I2080M	TCGA-85-A4QQ	LUSC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	0.1111
p.I2080M	DO45427	LUSC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	0.1111
p.R2095I	TCGA-AG-3892	READ	TCGA	DSGHRT	DEG_SCF_TRCP1_1	0.2778
p.R2095I	DO36394	READ	ICGC	DSGHRT	DEG_SCF_TRCP1_1	0.2778
p.D2087N	TCGA-B5-A1MR	UCEC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	0.3056
p.D2087N	TCGA-CA-6717	COAD	TCGA	DSGHRT	DEG_SCF_TRCP1_1	0.3056
p.D2087N	DO8264	COAD	ICGC	DSGHRT	DEG_SCF_TRCP1_1	0.3056
p.D2087N	DO41758	UCEC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	0.3056
p.N2100K	TCGA-C5-A7XC	CESC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	0.1389
p.N2100K	DO49896	CESC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	0.1389
p.N2100S	TCGA-D1-A17Q	UCEC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	0.1389
p.N2100S	DO41903	UCEC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	0.1389
p.A2083E	DO229027	LICA	ICGC	DSGHRT	DEG_SCF_TRCP1_1	0.1944
p.N2082S	SIDM00672	Hepatocellular Carcinoma	GDSC	DSGHRT	DEG_SCF_TRCP1_1	0.1667
p.R2095S	SIDM00282	Colorectal Carcinoma	GDSC	DSGHRT	DEG_SCF_TRCP1_1	0.2778
p.R2095S	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGHRT	DEG_SCF_TRCP1_1	0.2778
p.R2095S	CW-2	large_intestine	COSMIC	DSGHRT	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SCF_TRCP1_1	2088:2093	DSGHRT	BTRC	0.7994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons