DegronMD

Uniprot ID: Q6GYQ0

Source protein: Ral GTPase-activating protein subunit alpha-1

Source gene: RALGAPA1

Class: DEG_COP1_1

Location: 831:838

E3 ligase: COP1

DEGRON score: 0.9985

ASA_SCORE: 75.9875

COIL: 0.7659

CONS_SCORE: 0.2929

DSS_SCORE: 0.4917

HELIX: 0.2126

FCONS_SCORE: 0.9958

RIG_SCORE: 0.6823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R846Q	TCGA-AJ-A5DW	UCEC	TCGA	SSANVPDL	DEG_COP1_1	0.1111
p.R846Q	DO50075	UCEC	ICGC	SSANVPDL	DEG_COP1_1	0.1111
p.E841K	TCGA-D8-A1JA	BRCA	TCGA	SSANVPDL	DEG_COP1_1	0.25
p.E841K	DO2819	BRCA	ICGC	SSANVPDL	DEG_COP1_1	0.25
p.P823A	TCGA-D9-A4Z6	SKCM	TCGA	SSANVPDL	DEG_COP1_1	0.1111
p.P823A	DO47485	SKCM	ICGC	SSANVPDL	DEG_COP1_1	0.1111
p.L847V	TCGA-DD-AACV	LIHC	TCGA	SSANVPDL	DEG_COP1_1	0.0833
p.L847V	DO219565	LIHC	ICGC	SSANVPDL	DEG_COP1_1	0.0833
p.G830S	TCGA-E2-A10A	BRCA	TCGA	SSANVPDL	DEG_COP1_1	0.3056
p.G830S	DO1376	BRCA	ICGC	SSANVPDL	DEG_COP1_1	0.3056
p.G830S	DO229030	LICA	ICGC	SSANVPDL	DEG_COP1_1	0.3056
p.R848Q	TCGA-EY-A1G8	UCEC	TCGA	SSANVPDL	DEG_COP1_1	0.0556
p.R848Q	DO43578	UCEC	ICGC	SSANVPDL	DEG_COP1_1	0.0556
p.P836H	DO229015	LICA	ICGC	SSANVPDL	DEG_COP1_1	0.7694
p.L838M	DO229041	LICA	ICGC	SSANVPDL	DEG_COP1_1	0.5999
p.S825Y	DO26475	LUSC	ICGC	SSANVPDL	DEG_COP1_1	0.1667
p.I844L	SIDM00845	Burkitt's Lymphoma	GDSC	SSANVPDL	DEG_COP1_1	0.1667
p.I844L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SSANVPDL	DEG_COP1_1	0.1667
p.S839P	SIDM01608	Endometrial Carcinoma	GDSC	SSANVPDL	DEG_COP1_1	0.3056
p.E824D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SSANVPDL	DEG_COP1_1	0.1389
p.E824D	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	SSANVPDL	DEG_COP1_1	0.1389
p.N834H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SSANVPDL	DEG_COP1_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_COP1_1	831:838	SSANVPDL	COP1	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons