DegronMD

Uniprot ID: Q6GYQ0

Source protein: Ral GTPase-activating protein subunit alpha-1

Source gene: RALGAPA1

Class: DEG_APCC_DBOX_1

Location: 1765:1773

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6667

ASA_SCORE: 23.9778

COIL: 0.1932

CONS_SCORE: 0.5433

DSS_SCORE: 0.0409

HELIX: 0.7978

FCONS_SCORE: 1.424

RIG_SCORE: 0.9023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1781M	TCGA-AA-A022	COAD	TCGA	CRLLLSILG	DEG_APCC_DBOX_1	0.1111
p.R1781M	DO10647	COAD	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	0.1111
p.Q1756P	TCGA-EE-A29P	SKCM	TCGA	CRLLLSILG	DEG_APCC_DBOX_1	0.0833
p.Q1756P	DO37916	SKCM	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	0.0833
p.L1768F	TCGA-F5-6814	READ	TCGA	CRLLLSILG	DEG_APCC_DBOX_1	0.587
p.L1768F	DO36556	READ	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	0.587
p.P1758L	DO229010	COCA	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	0.1389
p.P1758L	DO229480	LAML	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	0.1389
p.S1768F	SIDM01682	Gastric Carcinoma	GDSC	CRLLLSILG	DEG_APCC_DBOX_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_APCC_DBOX_1	1765:1773	CRLLLSILG	APC,CDC20,FZR1	0.6667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons