DegronMD - Q92794(KAT6A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P997A	TCGA-14-1795	GBM	TCGA	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.6392
p.P997A	DO13114	GBM	ICGC	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.6392
p.L370F	TCGA-22-5477	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.L370F	DO26894	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.P1775L	TCGA-A2-A0CM	BRCA	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation altering degron motif	0.7582
p.P1775L	DO5682	BRCA	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation altering degron motif	0.7582
p.K1134N	TCGA-A5-A0G2	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation substituting flanking lysine	0.2778
p.K1134N	DO41235	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation substituting flanking lysine	0.2778
p.A1776D	TCGA-A5-A1OF	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.3056
p.A1776D	DO42568	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.3056
p.L1005I	TCGA-AN-A046	BRCA	TCGA	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.2222
p.L1005I	DO1285	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.2222
p.K365T	TCGA-AP-A056	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation substituting flanking lysine	0.1667
p.K365T	DO43971	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation substituting flanking lysine	0.1667
p.R366Q	TCGA-AX-A0J0	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0833
p.R366Q	DO41133	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0833
p.Q1757H	TCGA-AX-A1CE	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1111
p.Q1757H	DO42280	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1111
p.V1784A	TCGA-B5-A0JY	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.0833
p.V1784A	DO43041	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.0833
p.T369N	TCGA-B5-A1MX	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation blocking phosphorylation signal	0.6111
p.T369N	DO41999	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation blocking phosphorylation signal	0.6111
p.R386Q	TCGA-B5-A3FC	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.R386Q	DO233245	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.R386Q	DO41871	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.R386Q	SIDM00948	Burkitt's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.T1778N	TCGA-BP-5181	KIRC	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.25
p.T1778N	DO17263	KIRC	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.25
p.S1772N	TCGA-BR-4184	STAD	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation altering degron motif	0.7069
p.S1772N	DO38328	STAD	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation altering degron motif	0.7069
p.E380D	TCGA-CA-6718	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.3056
p.E380D	DO7801	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.3056
p.P994L	TCGA-CG-5733	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.25
p.P994L	DO38551	STAD	ICGC	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.25
p.P994L	SIDM00014	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.25
p.P994L	LIM1215	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.25
p.G382E	TCGA-CR-7368	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.25
p.G382E	DO14167	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.25
p.K1150T	TCGA-CZ-4853	KIRC	TCGA	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation substituting flanking lysine	0.2778
p.K1150T	DO16111	KIRC	ICGC	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation substituting flanking lysine	0.2778
p.Q849R	TCGA-D7-8572	STAD	TCGA	PVSST	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1944
p.Q849R	DO47735	STAD	ICGC	PVSST	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1944
p.K367N	TCGA-DA-A1I5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation substituting flanking lysine	0.2222
p.K367N	DO37447	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation substituting flanking lysine	0.2222
p.S1779F	TCGA-EE-A2MD	SKCM	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.2222
p.S1779F	DO222434	MELA	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.2222
p.S1779F	DO37851	SKCM	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.2222
p.S1779F	SIDM00545	Melanoma	GDSC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.2222
p.S1779F	ACH-000987	Skin Cancer	CCLE	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.2222
p.S1779F	Mewo	skin	COSMIC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.2222
p.V1784G	TCGA-EO-A3AV	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.0833
p.V1784G	DO52412	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.0833
p.V1784G	SIDM01310	Esophageal Carcinoma	GDSC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.0833
p.E380K	TCGA-GF-A6C9	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.3056
p.E380K	DO51254	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.3056
p.R386W	TCGA-HF-A5NB	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.R386W	DO50127	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.E380A	DO223053	ESCA	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.3056
p.P1153S	DO233920	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation rewiring degron network	0.0833
p.K1148M	DO232027	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation substituting flanking lysine	0.3333
p.S372R	DO229022	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.25
p.H853N	DO229038	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.0833
p.P1770T	DO229008	LICA	ICGC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation altering degron motif	0.5919
p.K1134R	DO23312	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation substituting flanking lysine	0.2778
p.S1000I	DO50672	ORCA	ICGC	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.7341
p.S1783T	SIDM00199	Chondrosarcoma	GDSC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1111
p.S1783T	ACH-002099	Bone Cancer	CCLE	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1111
p.S1783T	CS1	bone	COSMIC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1111
p.Y1780C	SIDM00876	Non-Cancerous	GDSC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1944
p.Y1780C	SIDM00877	Breast Carcinoma	GDSC	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1944
p.Y1780C	ACH-000196	Breast Cancer	CCLE	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1944
p.Y1780C	ACH-002374	Non-Cancerous	CCLE	DPHAMPYSHSP	CBL_PTK	1765:1775	Mutation rewiring degron network	0.1944
p.K848N	SIDM01503	Small Cell Lung Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	840:844	Mutation substituting flanking lysine	0.3333
p.K848N	ACH-000844	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	840:844	Mutation substituting flanking lysine	0.3333
p.D1141Y	ACH-000676	Brain Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	1140:1144	Mutation altering degron motif	0.6214
p.R998L	ACH-000961	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.7316

Kaplan plot for KAT6A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KAT6A

UniProt ID: Q92794

Entrez ID: 7994

Protein name: Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KAT6A in