DegronMD

Uniprot ID: Q92794

Source protein: Histone acetyltransferase KAT6A

Source gene: KAT6A

Class: DEG_SPOP_SBC_1

Location: 1140:1144

E3 ligase: SPOP

DEGRON score: 0.9558

ASA_SCORE: 95.1

COIL: 0.9322

CONS_SCORE: 0.3754

DSS_SCORE: 0.6645

HELIX: 0.0372

FCONS_SCORE: 1.0099

RIG_SCORE: 0.6655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1134N	TCGA-A5-A0G2	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.K1134N	DO41235	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.K1150T	TCGA-CZ-4853	KIRC	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.K1150T	DO16111	KIRC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.P1153S	DO233920	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.0833
p.K1148M	DO232027	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.3333
p.K1134R	DO23312	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.D1141Y	ACH-000676	Brain Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons