DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_SPOP_SBC_1

Location: 2035:2039

E3 ligase: SPOP

DEGRON score: 0.9975

ASA_SCORE: 89.38

COIL: 0.866

CONS_SCORE: 0.4649

DSS_SCORE: 0.435

HELIX: 0.1098

FCONS_SCORE: 1.0081

RIG_SCORE: 0.7552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2037A	TCGA-34-7107	LUSC	TCGA	PDTST	DEG_SPOP_SBC_1	0.825
p.T2037A	DO26449	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	0.825
p.E2046D	TCGA-AA-3984	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1389
p.E2046D	TCGA-AG-A002	READ	TCGA	PDTST	DEG_SPOP_SBC_1	0.1389
p.E2046D	TCGA-E6-A1LX	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.1389
p.E2046D	DO9002	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.E2046D	DO41020	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.R2033Q	TCGA-AA-A010	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.R2033Q	TCGA-EO-A22U	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.R2033Q	DO43755	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.E2043K	TCGA-FW-A3R5	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.2222
p.E2043K	DO228114	EOPC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2222
p.E2043K	DO37406	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.2222
p.C2041F	DO229045	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.Y2040C	SIDM01608	Endometrial Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.75
p.Y2040C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.75
p.T2037I	SIDM01659	Kidney Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.8189
p.T2037I	ACH-000313	Kidney Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons