DegronMD

Uniprot ID: Q7Z7G8

Source protein: Intermembrane lipid transfer protein VPS13B

Source gene: VPS13B

Class: DEG_SPOP_SBC_1

Location: 1274:1278

E3 ligase: SPOP

DEGRON score: 0.8975

ASA_SCORE: 89.9

COIL: 0.8674

CONS_SCORE: 0.5334

DSS_SCORE: 0.6816

HELIX: 0.049

FCONS_SCORE: 1.197

RIG_SCORE: 0.6258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1279Y	TCGA-AP-A051	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.3056
p.C1279Y	DO42673	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.3056
p.A1272T	TCGA-DU-6392	LGG	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.A1272T	DO22237	LGG	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.A1272T	SIDM01307	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2778
p.P1264S	TCGA-EE-A2A2	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.0556
p.P1264S	DO37583	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.P1264A	TCGA-XF-AAN3	BLCA	TCGA	PDTST	DEG_SPOP_SBC_1	0.0556
p.P1264A	DO219053	BLCA	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.P1274L	DO233797	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.7582
p.I1269V	DO49116	PACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1944
p.T1276I	SIDM00928	Breast Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.7078
p.T1276I	CAL-85-1	breast	COSMIC	PDTST	DEG_SPOP_SBC_1	0.7078
p.P1264T	SIDM00562	Breast Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.0556
p.P1264T	ACH-002163	Breast Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.0556
p.P1264T	MRK-nu-1	breast	COSMIC	PDTST	DEG_SPOP_SBC_1	0.0556
p.T1271S	SIDM00710	Small Cell Lung Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons