DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PDTST
Uniprot ID:
A6NNM3
Source protein:
RIMS-binding protein 3B
Source gene:
RIMBP3B
Class:
DEG_SPOP_SBC_1
Location:
315:319
E3 ligase:
SPOP
DEGRON score:
0.5384
ASA_SCORE:
89.68
COIL:
0.9262
CONS_SCORE:
0.3185
DSS_SCORE:
0.8526
HELIX:
0.041
FCONS_SCORE:
0.9021
RIG_SCORE:
0.4492
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RIMBP3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PDTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P46821
Microtubule-associated protein 1B
DEG_SPOP_SBC_1
2035:2039
PDTST
SPOP
0.9975
More...
P52756
RNA-binding protein 5
DEG_SPOP_SBC_1
457:461
PDTST
SPOP
0.9481
More...
Q7Z7G8
Intermembrane lipid transfer protein VPS13B
DEG_SPOP_SBC_1
1274:1278
PDTST
SPOP
0.8975
More...
Q8NDL9
Cytosolic carboxypeptidase-like protein 5
DEG_SPOP_SBC_1
229:233
PDTST
SPOP
0.8141
More...
Q8WZ75
Roundabout homolog 4
DEG_SPOP_SBC_1
576:580
PDTST
SPOP
0.9187
More...
Q92794
Histone acetyltransferase KAT6A
DEG_SPOP_SBC_1
1140:1144
PDTST
SPOP
0.9558
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
236:240
PDTST
SPOP
0.9814
More...
Q96GD3
Polycomb protein SCMH1
DEG_SPOP_SBC_1
337:341
PDTST
SPOP
0.9895
More...
Q96LR2
Leucine rich adaptor protein 1
DEG_SPOP_SBC_1
131:135
PDTST
SPOP
0.9852
More...
Q9NZP6
Nuclear pore-associated protein 1
DEG_SPOP_SBC_1
676:680
PDTST
SPOP
0.9536
More...
Q9NZP6
Nuclear pore-associated protein 1
DEG_SPOP_SBC_1
801:805
PDTST
SPOP
0.9687
More...
Q9UFD9
RIMS-binding protein 3A
DEG_SPOP_SBC_1
315:319
PDTST
SPOP
0.9775
More...
A6NJZ7
RIMS-binding protein 3C
DEG_SPOP_SBC_1
315:319
PDTST
SPOP
0.5006
More...
A6NNM3
RIMS-binding protein 3B
DEG_SPOP_SBC_1
315:319
PDTST
SPOP
0.5384
More...
Q8N9M1
Uncharacterized protein C19orf47
DEG_SPOP_SBC_1
160:164
PDTST
SPOP
0.9381
More...