DegronMD - Q8WZ75(ROBO4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L624F	TCGA-39-5016	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.25
p.L624F	DO26701	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.25
p.P868H	TCGA-46-3769	LUSC	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation altering degron motif	0.6583
p.P868H	DO26590	LUSC	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation altering degron motif	0.6583
p.R627H	TCGA-49-4514	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.R627H	TCGA-B5-A11H	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.R627H	DO23818	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.R627H	DO42825	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.R627L	TCGA-49-AAR9	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.R627L	DO218921	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.G878R	TCGA-85-7950	LUSC	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.0833
p.G878R	DO26878	LUSC	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.0833
p.D566N	TCGA-86-8281	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.0556
p.D566N	DO26318	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.0556
p.G871A	TCGA-AG-A01N	READ	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2778
p.P609L	TCGA-B5-A1MX	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.P609L	DO41999	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.I586M	TCGA-DR-A0ZM	CESC	TCGA	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1667
p.I586M	DO6254	CESC	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1667
p.W954C	TCGA-EE-A2MD	SKCM	TCGA	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2222
p.E870K	TCGA-EJ-5514	PRAD	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.3056
p.E870K	DO36374	PRAD	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.3056
p.G571C	TCGA-EO-A22R	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1944
p.G571C	DO42713	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1944
p.G629R	TCGA-GN-A266	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.G629R	DO37432	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.P952T	TCGA-KK-A8ID	PRAD	TCGA	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2778
p.K852N	TCGA-V5-A7RC	ESCA	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation substituting flanking lysine	0.1667
p.R631H	DO9698	COAD	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.0556
p.D622E	DO233177	GACA	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.3056
p.D622E	DO231204	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.3056
p.G876C	DO233239	GACA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1389
p.A587V	DO233737	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1389
p.R568Q	DO233888	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1111
p.P570L	DO11854	GBM	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1667
p.L864P	DO224627	LAML	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation altering degron motif	0.6471
p.S610R	DO228974	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1389
p.D577E	DO229019	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation altering degron motif	0.5647
p.S626R	DO229029	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1944
p.Q610K	DO229022	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1389
p.C863F	DO229052	LICA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation altering degron motif	0.5996
p.L574P	DO224638	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.2778
p.W877L	DO231033	LUSC	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1111
p.G854R	DO220878	MELA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1111
p.G854R	DO229462	SKCA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1111
p.G854R	SIDM00890	Melanoma	GDSC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1111
p.G854R	ACH-000580	Skin Cancer	CCLE	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1111
p.G854R	C32	skin	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1111
p.S621F	DO222843	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7982
p.A628D	DO28893	OV	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1389
p.D622V	DO46897	RECA	ICGC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.3056
p.P858S	DO219466	SKCM	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2222
p.R940W	SIDM00499	Prostate Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.25
p.R940W	ACH-000956	Prostate Cancer	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.25
p.R940W	22RV1	prostate	COSMIC	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.25
p.L873S	SIDM00945	Colorectal Carcinoma	GDSC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2222
p.L873S	ACH-000895	Colon/Colorectal Cancer	CCLE	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2222
p.L873S	CL-34	large intestine	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2222
p.D941V	SIDM00043	Head and Neck Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2778
p.D941V	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2778
p.D941V	SIDM00115	Head and Neck Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2778
p.D941V	ACH-001148	Lymphoma	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2778
p.D941V	ACH-002297	Head and Neck Cancer	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2778
p.D941V	ACH-002298	Head and Neck Cancer	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	943:950	Mutation rewiring degron network	0.2778
p.A587P	SIDM00660	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1389
p.A587P	ACH-000985	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1389
p.A587P	LS-411N	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1389
p.L589M	SIDM00057	Neuroblastoma	GDSC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.0833
p.L589M	SIDM00552	Rhabdomyosarcoma	GDSC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.0833
p.L589M	ACH-000607	Rhabdoid	CCLE	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.0833
p.L589M	KYM-1	soft tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.0833
p.Q613L	SIDM01134	Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.Q613L	ACH-000292	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.Q613L	NCI-H841	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.G629A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.G629A	ACH-000929	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.G629A	NCI-H2110	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.V572M	SIDM00560	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.2222
p.V572M	MKN7	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.2222
p.C618Y	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.5976
p.C618Y	ACH-000916	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.5976
p.C618Y	NCI-H1573	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.5976
p.C858Y	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2222
p.C858Y	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2222
p.S619F	SIDM00011	Melanoma	GDSC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7982
p.S619F	ACH-000477	Skin Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7982
p.G629E	SIDM00497	Colorectal Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.E578K	MEL-HO	skin	COSMIC	PDTST	DEG_SPOP_SBC_1	576:580	Mutation altering degron motif	0.7022
p.P607A	EW-18	bone	COSMIC	PCSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.0556
p.P852H	SW1990	pancreas	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	862:869	Mutation substituting flanking lysine	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ROBO4

UniProt ID: Q8WZ75

Entrez ID: 54538

Protein name: Roundabout homolog 4 (Magic roundabout)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ROBO4 in