DegronMD

Uniprot ID: Q8WZ75

Source protein: Roundabout homolog 4

Source gene: ROBO4

Class: DEG_SCF_FBW7_1

Location: 862:869

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 74.85

COIL: 0.9309

CONS_SCORE: 0.7626

DSS_SCORE: 0.4787

HELIX: 0.0325

FCONS_SCORE: 1.1193

RIG_SCORE: 0.7197

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P868H	TCGA-46-3769	LUSC	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	0.6583
p.P868H	DO26590	LUSC	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.6583
p.L864P	DO224627	LAML	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.6471
p.C863F	DO229052	LICA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.5996
p.E870K	TCGA-EJ-5514	PRAD	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	0.3056
p.E870K	DO36374	PRAD	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.3056
p.G871A	TCGA-AG-A01N	READ	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	0.2778
p.P858S	DO219466	SKCM	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.2222
p.L873S	SIDM00945	Colorectal Carcinoma	GDSC	PCLTPTPS	DEG_SCF_FBW7_1	0.2222
p.L873S	ACH-000895	Colon/Colorectal Cancer	CCLE	PCLTPTPS	DEG_SCF_FBW7_1	0.2222
p.L873S	CL-34	large_intestine	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	0.2222
p.C858Y	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCLTPTPS	DEG_SCF_FBW7_1	0.2222
p.C858Y	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	0.2222
p.K852N	TCGA-V5-A7RC	ESCA	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	0.1667
p.P852H	SW1990	pancreas	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	0.1667
p.G876C	DO233239	GACA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.1389
p.W877L	DO231033	LUSC	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.1111
p.G854R	DO220878	MELA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.1111
p.G854R	DO229462	SKCA	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.1111
p.G854R	SIDM00890	Melanoma	GDSC	PCLTPTPS	DEG_SCF_FBW7_1	0.1111
p.G854R	ACH-000580	Skin Cancer	CCLE	PCLTPTPS	DEG_SCF_FBW7_1	0.1111
p.G854R	C32	skin	COSMIC	PCLTPTPS	DEG_SCF_FBW7_1	0.1111
p.G878R	TCGA-85-7950	LUSC	TCGA	PCLTPTPS	DEG_SCF_FBW7_1	0.0833
p.G878R	DO26878	LUSC	ICGC	PCLTPTPS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ75	Roundabout homolog 4	DEG_SCF_FBW7_1	862:869	PCLTPTPS	FBXW7	0.9979	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons