DegronMD

Uniprot ID: Q8WZ75

Source protein: Roundabout homolog 4

Source gene: ROBO4

Class: DEG_SPOP_SBC_1

Location: 617:621

E3 ligase: SPOP

DEGRON score: 0.8344

ASA_SCORE: 66.02

COIL: 0.8316

CONS_SCORE: 0.668

DSS_SCORE: 0.4751

HELIX: 0.1018

FCONS_SCORE: 0.991

RIG_SCORE: 0.6224

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L624F	TCGA-39-5016	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.25
p.L624F	DO26701	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.25
p.R627H	TCGA-49-4514	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1667
p.R627H	TCGA-B5-A11H	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1667
p.R627H	DO23818	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.R627H	DO42825	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.R627L	TCGA-49-AAR9	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1667
p.R627L	DO218921	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1667
p.P609L	TCGA-B5-A1MX	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1111
p.P609L	DO41999	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.G629R	TCGA-GN-A266	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1111
p.G629R	DO37432	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.R631H	DO9698	COAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.D622E	DO233177	GACA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.3056
p.D622E	DO231204	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.3056
p.S610R	DO228974	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1389
p.S626R	DO229029	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1944
p.Q610K	DO229022	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1389
p.S621F	DO222843	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.7982
p.A628D	DO28893	OV	ICGC	PCSSS	DEG_SPOP_SBC_1	0.1389
p.D622V	DO46897	RECA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.3056
p.Q613L	SIDM01134	Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.2222
p.Q613L	ACH-000292	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.2222
p.Q613L	NCI-H841	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.2222
p.G629A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.G629A	ACH-000929	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.1111
p.G629A	NCI-H2110	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.C618Y	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.5976
p.C618Y	ACH-000916	Lung Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.5976
p.C618Y	NCI-H1573	lung	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.5976
p.S619F	SIDM00011	Melanoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.7982
p.S619F	ACH-000477	Skin Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.7982
p.G629E	SIDM00497	Colorectal Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.P607A	EW-18	bone	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCSSS

Degron related mutations and impact score

Drug responses associated with ROBO4 mutations

All proteins holding degron of PCSSS