DegronMD

Uniprot ID: Q9Y5P3

Source protein: Retinoic acid-induced protein 2

Source gene: RAI2

Class: DEG_SPOP_SBC_1

Location: 145:149

E3 ligase: SPOP

DEGRON score: 0.7764

ASA_SCORE: 64.4

COIL: 0.8578

CONS_SCORE: 0.6201

DSS_SCORE: 0.4034

HELIX: 0.0886

FCONS_SCORE: 0.9747

RIG_SCORE: 0.6539

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S149R	TCGA-51-6867	LUSC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.7427
p.S149R	DO26477	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.7427
p.S147Y	TCGA-55-8506	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.712
p.S147Y	DO45390	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.712
p.P141T	TCGA-86-8073	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	0.2222
p.P141T	DO23624	LUAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.2222
p.L155F	TCGA-DI-A1BU	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	0.1667
p.T150N	TCGA-E9-A1RF	BRCA	TCGA	PCSSS	DEG_SPOP_SBC_1	0.3056
p.T150N	DO2665	BRCA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.3056
p.E143K	TCGA-EE-A3AA	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.2778
p.E143K	DO222632	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.2778
p.E143K	DO37571	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	0.2778
p.S147F	TCGA-ER-A19S	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.7982
p.S147F	TCGA-ER-A42L	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.7982
p.S147T	TCGA-FR-A726	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	0.6005
p.S147T	DO48665	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	0.6005
p.A144S	DO50341	ESAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.3056
p.G149W	DO26430	LUSC	ICGC	PCSSS	DEG_SPOP_SBC_1	0.7825
p.G158E	DO220881	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0833
p.E135K	DO46436	OV	ICGC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.G149R	DO38875	STAD	ICGC	PCSSS	DEG_SPOP_SBC_1	0.7568
p.N135D	SIDM00874	Breast Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.0556
p.N135D	ACH-000223	Breast Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.0556
p.P137H	SIDM01146	Gastric Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.P137H	ACH-000932	Gastric Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.1111
p.P137H	NCI-SNU-1	stomach	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.1111
p.P145S	SIDM00901	Endometrial Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	0.6752
p.P145S	ACH-000940	Endometrial/Uterine Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.6752
p.P145S	AN3-CA	endometrium	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.6752
p.P141Q	ACH-000467	Colon/Colorectal Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	0.2222
p.P141Q	HCC-56	large_intestine	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.2222
p.Q139H	LNZTA3WT4	central_nervous_system	COSMIC	PCSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	407:411	PCSSS	SPOP	0.9876	More...
Q03167	Transforming growth factor beta receptor type 3	DEG_SPOP_SBC_1	844:848	PCSSS	SPOP	0.998	More...
Q5T749	Keratinocyte proline-rich protein	DEG_SPOP_SBC_1	277:281	PCSSS	SPOP	0.9032	More...
Q6W2J9	BCL-6 corepressor	DEG_SPOP_SBC_1	1435:1439	PCSSS	SPOP	0.935	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	403:407	PCSSS	SPOP	0.772	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SPOP_SBC_1	78:82	PCSSS	SPOP	0.992	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	617:621	PCSSS	SPOP	0.8344	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	94:98	PCSSS	SPOP	0.9963	More...
Q9NWZ8	Gem-associated protein 8	DEG_SPOP_SBC_1	87:91	PCSSS	SPOP	0.9101	More...
Q8TC76	Protein FAM110B	DEG_SPOP_SBC_1	216:220	PCSSS	SPOP	0.9592	More...
Q9BU23	Lipase maturation factor 2	DEG_SPOP_SBC_1	695:699	PCSSS	SPOP	0.9238	More...
Q9Y5P3	Retinoic acid-induced protein 2	DEG_SPOP_SBC_1	145:149	PCSSS	SPOP	0.7764	More...
Q7Z736	Pleckstrin homology domain-containing family H member 3	DEG_SPOP_SBC_1	755:759	PCSSS	SPOP	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCSSS

Degron related mutations and impact score

Drug responses associated with RAI2 mutations

All proteins holding degron of PCSSS