DegronMD - Q9NWZ8(GEMIN8)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q98K	TCGA-17-Z037	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.H80Y	TCGA-17-Z057	LUAD	TCGA	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.W83L	TCGA-AK-3440	KIRC	TCGA	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.Y86C	TCGA-DI-A1BU	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.Y86C	DO42023	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.S96Y	TCGA-EY-A215	UCEC	TCGA	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.S96Y	DO42665	UCEC	ICGC	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.H79N	DO229028	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1111
p.R95I	SIDM01090	Colorectal Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.R95I	ACH-000943	Colon/Colorectal Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.R95I	RKO	large intestine	COSMIC	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.G97E	SIDM00150	Colorectal Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1667
p.G97E	ACH-000969	Colon/Colorectal Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1667
p.G97E	KM12	large intestine	COSMIC	PCSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons