DegronMD - O75385(ULK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T636A	TCGA-05-4424	LUAD	TCGA	SPTKAVPSF	DEG_COP1_1	623:631	Mutation blocking phosphorylation signal	0.6389
p.T636A	DO23672	LUAD	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation blocking phosphorylation signal	0.6389
p.R603W	TCGA-AG-3742	READ	TCGA	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0556
p.R603W	DO36384	READ	ICGC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0556
p.R603W	SIDM00839	Colorectal Carcinoma	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0556
p.R603W	LoVo	large intestine	COSMIC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0556
p.P637T	TCGA-AY-6197	COAD	TCGA	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.1667
p.P637T	DO9956	COAD	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.1667
p.P637S	TCGA-D1-A17H	UCEC	TCGA	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.1667
p.P637S	DO41847	UCEC	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.1667
p.P431L	TCGA-D3-A8GI	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1389
p.P431L	DO50284	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1389
p.S623F	TCGA-D3-A8GQ	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.9093
p.S623F	DO51246	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.9093
p.S403F	TCGA-EE-A29T	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.6667
p.S403F	DO37742	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.6667
p.P402Q	TCGA-EE-A2MP	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.P402Q	DO37818	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.P414S	TCGA-EE-A3J5	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.25
p.P414S	TCGA-EE-A3J5	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.P414S	DO47331	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.25
p.P414S	DO47331	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.G416C	TCGA-ER-A19P	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.G416C	TCGA-ER-A19P	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2222
p.G416C	DO47623	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.G416C	DO47623	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2222
p.S422Y	TCGA-FS-A1ZG	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.712
p.S422Y	DO37523	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.712
p.P412H	TCGA-FS-A1ZU	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.3056
p.P412H	TCGA-FS-A1ZU	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1111
p.P412H	DO37723	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.3056
p.P412H	DO37723	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1111
p.P629L	TCGA-FW-A3R5	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.7582
p.P629L	DO37406	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.7582
p.P624H	TCGA-GN-A265	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.6583
p.P624H	DO37491	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.6583
p.G604C	TCGA-MP-A4T7	LUAD	TCGA	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0833
p.G604C	DO45370	LUAD	ICGC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0833
p.S630F	TCGA-QB-A6FS	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.9093
p.S630F	DO48654	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.9093
p.R417W	TCGA-XV-AAZW	SKCM	TCGA	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1667
p.R417W	TCGA-XV-AAZW	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.25
p.R417W	DO219495	SKCM	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1667
p.R417W	DO219495	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.25
p.G399C	DO229024	LICA	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1111
p.S630Y	DO228593	MALY	ICGC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.8231
p.P414L	DO220891	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.25
p.P414L	DO220891	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.P404S	DO222843	MELA	ICGC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.25
p.P404S	SIDM00545	Melanoma	GDSC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.25
p.P404S	ACH-000987	Skin Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.25
p.P404S	Mewo	skin	COSMIC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.25
p.V434I	DO233472	PRAD	ICGC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.0556
p.A418T	SIDM00450	Acute Myeloid Leukemia	GDSC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.A418T	SIDM00450	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.A418T	SIDM00061	Ovarian Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.A418T	SIDM00061	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.A418T	SIDM00235	Kidney Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.A418T	SIDM00235	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.A418T	PL-21	haematopoietic and lymphoid tissue	COSMIC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.A418T	PL-21	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.A418T	RCC10RGB	kidney	COSMIC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.A418T	RCC10RGB	kidney	COSMIC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.R603Q	SIDM00834	Colorectal Carcinoma	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0556
p.R603Q	ACH-000470	Colon/Colorectal Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0556
p.R603Q	SW1463	large intestine	COSMIC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.0556
p.C426R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.C426R	ACH-000953	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.C426R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.P634L	SIDM00217	Colorectal Carcinoma	GDSC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.25
p.Q640K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.0833
p.Q640K	ACH-001127	Leukemia	CCLE	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.0833
p.Q640K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.0833
p.N615Y	SIDM00667	Other Sarcomas	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation altering degron motif	0.5948
p.N615Y	ACH-002246	Sarcoma	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation altering degron motif	0.5948
p.N615Y	Hs633T	soft tissue	COSMIC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation altering degron motif	0.5948
p.L621M	SIDM01608	Endometrial Carcinoma	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation altering degron motif	0.5999
p.L621M	ACH-000990	Endometrial/Uterine Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation altering degron motif	0.5999
p.G399S	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1111
p.G399S	ACH-000726	Esophageal Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1111
p.G622V	ACH-000659	Lung Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.3056
p.G622V	ACH-000659	Lung Cancer	CCLE	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.3056
p.G622V	ACH-001386	Lung Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	613:621	Mutation rewiring degron network	0.3056
p.G622V	ACH-001386	Lung Cancer	CCLE	SPTKAVPSF	DEG_COP1_1	623:631	Mutation rewiring degron network	0.3056
p.A428T	ACH-001369	Ovarian Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2222
p.P624S	ACH-002238	Leukemia	CCLE	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.5641
p.P624S	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SPTKAVPSF	DEG_COP1_1	623:631	Mutation altering degron motif	0.5641

Kaplan plot for ULK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ULK1

UniProt ID: O75385

Entrez ID: 8408

Protein name: Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ULK1 in