DegronMD

Uniprot ID: O75385

Source protein: Serine/threonine-protein kinase ULK1

Source gene: ULK1

Class: DEG_APCC_DBOX_1

Location: 613:621

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9966

ASA_SCORE: 87.8333

COIL: 0.9251

CONS_SCORE: 0.3156

DSS_SCORE: 0.573

HELIX: 0.0392

FCONS_SCORE: 1.035

RIG_SCORE: 0.6754

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R603W	TCGA-AG-3742	READ	TCGA	QRNPLPPIL	DEG_APCC_DBOX_1	0.0556
p.R603W	DO36384	READ	ICGC	QRNPLPPIL	DEG_APCC_DBOX_1	0.0556
p.R603W	SIDM00839	Colorectal Carcinoma	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	0.0556
p.R603W	LoVo	large_intestine	COSMIC	QRNPLPPIL	DEG_APCC_DBOX_1	0.0556
p.G604C	TCGA-MP-A4T7	LUAD	TCGA	QRNPLPPIL	DEG_APCC_DBOX_1	0.0833
p.G604C	DO45370	LUAD	ICGC	QRNPLPPIL	DEG_APCC_DBOX_1	0.0833
p.R603Q	SIDM00834	Colorectal Carcinoma	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	0.0556
p.R603Q	ACH-000470	Colon/Colorectal Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	0.0556
p.R603Q	SW1463	large_intestine	COSMIC	QRNPLPPIL	DEG_APCC_DBOX_1	0.0556
p.N615Y	SIDM00667	Other Sarcomas	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	0.5948
p.N615Y	ACH-002246	Sarcoma	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	0.5948
p.N615Y	Hs633T	soft_tissue	COSMIC	QRNPLPPIL	DEG_APCC_DBOX_1	0.5948
p.L621M	SIDM01608	Endometrial Carcinoma	GDSC	QRNPLPPIL	DEG_APCC_DBOX_1	0.5999
p.L621M	ACH-000990	Endometrial/Uterine Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	0.5999
p.G622V	ACH-000659	Lung Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	0.3056
p.G622V	ACH-001386	Lung Cancer	CCLE	QRNPLPPIL	DEG_APCC_DBOX_1	0.3056

Drug responses associated with ULK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00132	PAAD\|pancreas	p.T309P (No)	GDSC	ULK1_4989	5.3414
SIDM01079	SKCM\|melanoma	p.P592S (No)	GDSC	ULK1_4989	29.915
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T309P (No)	GDSC	ULK1_4989	1.3211
SIDM00402	BLCA\|bladder	p.P574R (No)	GDSC	ULK1_4989	5.9027
SIDM00951	LAML\|acute_myeloid_leukaemia	p.Q173* (No)	GDSC	ULK1_4989	1.7846
SIDM00970	BLCA\|bladder	p.S330A (No)	GDSC	ULK1_4989	0.1396
SIDM00572	STAD\|stomach	p.G530S (No)	GDSC	ULK1_4989	9.3725
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R137H (No)	GDSC	ULK1_4989	10.609
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T180I (No)	GDSC	ULK1_4989	10.609
SIDM01045	UCEC\|endometrium	p.A822fs*2 (No)	GDSC	ULK1_4989	4.6391
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.T575fs*72 (No)	GDSC	ULK1_4989	1.057
SIDM00145	ALL\|lymphoblastic_leukemia	p.A85V (No)	GDSC	ULK1_4989	4.2854
SIDM00145	ALL\|lymphoblastic_leukemia	p.Q640K (No)	GDSC	ULK1_4989	4.2854
SIDM00121	ALL\|lymphoblastic_leukemia	p.A728T (No)	GDSC	ULK1_4989	2.4991
SIDM00121	ALL\|lymphoblastic_leukemia	p.R959H (No)	GDSC	ULK1_4989	2.4991
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R153H (No)	GDSC	ULK1_4989	2.0135
SIDM00901	UCEC\|endometrium	p.S147P (No)	GDSC	ULK1_4989	3.1329
SIDM00272	BRCA\|breast	p.E320K (No)	GDSC	ULK1_4989	4.1939
SIDM00831	HNSC\|head_and_neck	p.T309P (No)	GDSC	ULK1_4989	3.7859
SIDM00964	UNCLASSIFIED\|prostate	p.T309P (No)	GDSC	ULK1_4989	3.204
SIDM00859	DLBC\|B_cell_lymphoma	p.A332T (No)	GDSC	ULK1_4989	4.3188
SIDM00785	LAML\|acute_myeloid_leukaemia	p.T850M (No)	GDSC	ULK1_4989	31.177
SIDM01048	MM\|lymphoid_neoplasm_other	p.G762R (No)	GDSC	ULK1_4989	3.461
SIDM01007	ALL\|lymphoblastic_leukemia	p.R697H (No)	GDSC	ULK1_4989	2.9575
SIDM00537	COREAD\|large_intestine	p.P481fs*166 (No)	GDSC	ULK1_4989	9.3085
SIDM00235	KIRC\|kidney	p.A418T (No)	GDSC	ULK1_4989	790.31
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.E73K (No)	GDSC	ULK1_4989	27.268
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.I620fs*27 (Yes)	GDSC	ULK1_4989	2.6755
SIDM01090	COREAD\|large_intestine	p.A711V (No)	GDSC	ULK1_4989	10.414
SIDM01020	MM\|myeloma	p.G301S (No)	GDSC	ULK1_4989	1.6816
SIDM00505	PAAD\|pancreas	p.A705V (No)	GDSC	ULK1_4989	5.366
SIDM00137	LUAD\|lung_NSCLC_adenocarcinoma	p.S310P (No)	GDSC	ULK1_4989	8.0359
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R553fs*92 (No)	GDSC	ULK1_4989	8.1576
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.Q965K (No)	GDSC	ULK1_4989	2.2765
SIDM00217	COREAD\|large_intestine	p.R266C (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.P435L (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.P634L (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.R697H (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.R845C (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.S1042T (No)	GDSC	ULK1_4989	11.825
SIDM01083	HNSC\|head_and_neck	p.T309P (No)	GDSC	ULK1_4989	26.992
SIDM00280	UNCLASSIFIED\|stomach	p.S298L (No)	GDSC	ULK1_4989	7.2778
SIDM00839	COREAD\|large_intestine	p.R603W (Yes)	GDSC	ULK1_4989	67.4
SIDM00231	KIRC\|kidney	p.T309P (No)	GDSC	ULK1_4989	18.479
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N559K (No)	GDSC	ULK1_4989	6.5064
SIDM00150	COREAD\|large_intestine	p.P435L (No)	GDSC	ULK1_4989	908.87
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T309P (No)	GDSC	ULK1_4989	13.336
SIDM00587	UNCLASSIFIED\|biliary_tract	p.P714R (No)	GDSC	ULK1_4989	4.1074
SIDM00810	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R458G (No)	GDSC	ULK1_4989	6.9311
SIDM01189	GBM\|glioma	p.D700G (No)	GDSC	ULK1_4989	20.045
SIDM00257	NB\|neuroblastoma	p.A711V (No)	GDSC	ULK1_4989	7.9723
SIDM01205	DLBC\|B_cell_lymphoma	p.T309P (No)	GDSC	ULK1_4989	2.7822
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.T309P (No)	GDSC	ULK1_4989	55.606
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S317F (No)	GDSC	ULK1_4989	55.606
SIDM00273	LGG\|glioma	p.G762R (No)	GDSC	ULK1_4989	7.0212
SIDM00487	COREAD\|large_intestine	p.A125T (No)	GDSC	ULK1_4989	600.8
SIDM00282	COREAD\|large_intestine	p.Q767fs*35 (No)	GDSC	ULK1_4989	752.22
SIDM00114	MESO\|mesothelioma	p.K686M (No)	GDSC	ULK1_4989	257.45
SIDM00114	MESO\|mesothelioma	p.P805S (No)	GDSC	ULK1_4989	257.45
SIDM00241	BRCA\|breast	p.R691Q (No)	GDSC	ULK1_4989	0.9961
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.S784C (No)	GDSC	ULK1_4989	47.132
SIDM00541	COREAD\|large_intestine	p.E718D (No)	GDSC	ULK1_4989	6.2698
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.C426R (No)	GDSC	ULK1_4989	2.6777
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.V489I (No)	GDSC	ULK1_4989	48.352
SIDM00046	LUAD\|lung_NSCLC_adenocarcinoma	p.T309P (No)	GDSC	ULK1_4989	6.872
SIDM00834	COREAD\|large_intestine	p.R603Q (Yes)	GDSC	ULK1_4989	176.03
SIDM01259	ALL\|lymphoblastic_leukemia	p.P624S (Yes)	GDSC	ULK1_4989	5.9154
SIDM00457	MM\|myeloma	p.G762R (No)	GDSC	ULK1_4989	2.3387
SIDM00562	BRCA\|breast	p.D576N (No)	GDSC	ULK1_4989	11.865
SIDM00123	KIRC\|kidney	p.T309P (No)	GDSC	ULK1_4989	52.632
SIDM00920	BRCA\|breast	p.P574R (No)	GDSC	ULK1_4989	2.5972
SIDM00118	COREAD\|large_intestine	p.E73D (No)	GDSC	ULK1_4989	3.5371

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRNPLPPIL

Degron related mutations and impact score

Drug responses associated with ULK1 mutations

All proteins holding degron of QRNPLPPIL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_APCC_DBOX_1	613:621	QRNPLPPIL	APC,CDC20,FZR1	0.9966	More...