DegronMD

Uniprot ID: O75385

Source protein: Serine/threonine-protein kinase ULK1

Source gene: ULK1

Class: DEG_COP1_1

Location: 623:631

E3 ligase: COP1

DEGRON score: 0.9972

ASA_SCORE: 81.1444

COIL: 0.9262

CONS_SCORE: 0.2716

DSS_SCORE: 0.5083

HELIX: 0.024

FCONS_SCORE: 0.9041

RIG_SCORE: 0.6818

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T636A	TCGA-05-4424	LUAD	TCGA	SPTKAVPSF	DEG_COP1_1	0.6389
p.T636A	DO23672	LUAD	ICGC	SPTKAVPSF	DEG_COP1_1	0.6389
p.P637T	TCGA-AY-6197	COAD	TCGA	SPTKAVPSF	DEG_COP1_1	0.1667
p.P637T	DO9956	COAD	ICGC	SPTKAVPSF	DEG_COP1_1	0.1667
p.P637S	TCGA-D1-A17H	UCEC	TCGA	SPTKAVPSF	DEG_COP1_1	0.1667
p.P637S	DO41847	UCEC	ICGC	SPTKAVPSF	DEG_COP1_1	0.1667
p.S623F	TCGA-D3-A8GQ	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	0.9093
p.S623F	DO51246	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	0.9093
p.P629L	TCGA-FW-A3R5	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	0.7582
p.P629L	DO37406	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	0.7582
p.P624H	TCGA-GN-A265	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	0.6583
p.P624H	DO37491	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	0.6583
p.S630F	TCGA-QB-A6FS	SKCM	TCGA	SPTKAVPSF	DEG_COP1_1	0.9093
p.S630F	DO48654	SKCM	ICGC	SPTKAVPSF	DEG_COP1_1	0.9093
p.S630Y	DO228593	MALY	ICGC	SPTKAVPSF	DEG_COP1_1	0.8231
p.P634L	SIDM00217	Colorectal Carcinoma	GDSC	SPTKAVPSF	DEG_COP1_1	0.25
p.Q640K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPTKAVPSF	DEG_COP1_1	0.0833
p.Q640K	ACH-001127	Leukemia	CCLE	SPTKAVPSF	DEG_COP1_1	0.0833
p.Q640K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SPTKAVPSF	DEG_COP1_1	0.0833
p.G622V	ACH-000659	Lung Cancer	CCLE	SPTKAVPSF	DEG_COP1_1	0.3056
p.G622V	ACH-001386	Lung Cancer	CCLE	SPTKAVPSF	DEG_COP1_1	0.3056
p.P624S	ACH-002238	Leukemia	CCLE	SPTKAVPSF	DEG_COP1_1	0.5641
p.P624S	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SPTKAVPSF	DEG_COP1_1	0.5641

Drug responses associated with ULK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00132	PAAD\|pancreas	p.T309P (No)	GDSC	ULK1_4989	5.3414
SIDM01079	SKCM\|melanoma	p.P592S (No)	GDSC	ULK1_4989	29.915
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T309P (No)	GDSC	ULK1_4989	1.3211
SIDM00402	BLCA\|bladder	p.P574R (No)	GDSC	ULK1_4989	5.9027
SIDM00951	LAML\|acute_myeloid_leukaemia	p.Q173* (No)	GDSC	ULK1_4989	1.7846
SIDM00970	BLCA\|bladder	p.S330A (No)	GDSC	ULK1_4989	0.1396
SIDM00572	STAD\|stomach	p.G530S (No)	GDSC	ULK1_4989	9.3725
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R137H (No)	GDSC	ULK1_4989	10.609
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T180I (No)	GDSC	ULK1_4989	10.609
SIDM01045	UCEC\|endometrium	p.A822fs*2 (No)	GDSC	ULK1_4989	4.6391
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.T575fs*72 (No)	GDSC	ULK1_4989	1.057
SIDM00145	ALL\|lymphoblastic_leukemia	p.A85V (No)	GDSC	ULK1_4989	4.2854
SIDM00145	ALL\|lymphoblastic_leukemia	p.Q640K (Yes)	GDSC	ULK1_4989	4.2854
SIDM00121	ALL\|lymphoblastic_leukemia	p.A728T (No)	GDSC	ULK1_4989	2.4991
SIDM00121	ALL\|lymphoblastic_leukemia	p.R959H (No)	GDSC	ULK1_4989	2.4991
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R153H (No)	GDSC	ULK1_4989	2.0135
SIDM00901	UCEC\|endometrium	p.S147P (No)	GDSC	ULK1_4989	3.1329
SIDM00272	BRCA\|breast	p.E320K (No)	GDSC	ULK1_4989	4.1939
SIDM00831	HNSC\|head_and_neck	p.T309P (No)	GDSC	ULK1_4989	3.7859
SIDM00964	UNCLASSIFIED\|prostate	p.T309P (No)	GDSC	ULK1_4989	3.204
SIDM00859	DLBC\|B_cell_lymphoma	p.A332T (No)	GDSC	ULK1_4989	4.3188
SIDM00785	LAML\|acute_myeloid_leukaemia	p.T850M (No)	GDSC	ULK1_4989	31.177
SIDM01048	MM\|lymphoid_neoplasm_other	p.G762R (No)	GDSC	ULK1_4989	3.461
SIDM01007	ALL\|lymphoblastic_leukemia	p.R697H (No)	GDSC	ULK1_4989	2.9575
SIDM00537	COREAD\|large_intestine	p.P481fs*166 (No)	GDSC	ULK1_4989	9.3085
SIDM00235	KIRC\|kidney	p.A418T (No)	GDSC	ULK1_4989	790.31
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.E73K (No)	GDSC	ULK1_4989	27.268
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.I620fs*27 (Yes)	GDSC	ULK1_4989	2.6755
SIDM01090	COREAD\|large_intestine	p.A711V (No)	GDSC	ULK1_4989	10.414
SIDM01020	MM\|myeloma	p.G301S (No)	GDSC	ULK1_4989	1.6816
SIDM00505	PAAD\|pancreas	p.A705V (No)	GDSC	ULK1_4989	5.366
SIDM00137	LUAD\|lung_NSCLC_adenocarcinoma	p.S310P (No)	GDSC	ULK1_4989	8.0359
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R553fs*92 (No)	GDSC	ULK1_4989	8.1576
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.Q965K (No)	GDSC	ULK1_4989	2.2765
SIDM00217	COREAD\|large_intestine	p.R266C (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.P435L (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.P634L (Yes)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.R697H (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.R845C (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.S1042T (No)	GDSC	ULK1_4989	11.825
SIDM01083	HNSC\|head_and_neck	p.T309P (No)	GDSC	ULK1_4989	26.992
SIDM00280	UNCLASSIFIED\|stomach	p.S298L (No)	GDSC	ULK1_4989	7.2778
SIDM00839	COREAD\|large_intestine	p.R603W (No)	GDSC	ULK1_4989	67.4
SIDM00231	KIRC\|kidney	p.T309P (No)	GDSC	ULK1_4989	18.479
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N559K (No)	GDSC	ULK1_4989	6.5064
SIDM00150	COREAD\|large_intestine	p.P435L (No)	GDSC	ULK1_4989	908.87
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T309P (No)	GDSC	ULK1_4989	13.336
SIDM00587	UNCLASSIFIED\|biliary_tract	p.P714R (No)	GDSC	ULK1_4989	4.1074
SIDM00810	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R458G (No)	GDSC	ULK1_4989	6.9311
SIDM01189	GBM\|glioma	p.D700G (No)	GDSC	ULK1_4989	20.045
SIDM00257	NB\|neuroblastoma	p.A711V (No)	GDSC	ULK1_4989	7.9723
SIDM01205	DLBC\|B_cell_lymphoma	p.T309P (No)	GDSC	ULK1_4989	2.7822
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.T309P (No)	GDSC	ULK1_4989	55.606
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S317F (No)	GDSC	ULK1_4989	55.606
SIDM00273	LGG\|glioma	p.G762R (No)	GDSC	ULK1_4989	7.0212
SIDM00487	COREAD\|large_intestine	p.A125T (No)	GDSC	ULK1_4989	600.8
SIDM00282	COREAD\|large_intestine	p.Q767fs*35 (No)	GDSC	ULK1_4989	752.22
SIDM00114	MESO\|mesothelioma	p.K686M (No)	GDSC	ULK1_4989	257.45
SIDM00114	MESO\|mesothelioma	p.P805S (No)	GDSC	ULK1_4989	257.45
SIDM00241	BRCA\|breast	p.R691Q (No)	GDSC	ULK1_4989	0.9961
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.S784C (No)	GDSC	ULK1_4989	47.132
SIDM00541	COREAD\|large_intestine	p.E718D (No)	GDSC	ULK1_4989	6.2698
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.C426R (No)	GDSC	ULK1_4989	2.6777
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.V489I (No)	GDSC	ULK1_4989	48.352
SIDM00046	LUAD\|lung_NSCLC_adenocarcinoma	p.T309P (No)	GDSC	ULK1_4989	6.872
SIDM00834	COREAD\|large_intestine	p.R603Q (No)	GDSC	ULK1_4989	176.03
SIDM01259	ALL\|lymphoblastic_leukemia	p.P624S (Yes)	GDSC	ULK1_4989	5.9154
SIDM00457	MM\|myeloma	p.G762R (No)	GDSC	ULK1_4989	2.3387
SIDM00562	BRCA\|breast	p.D576N (No)	GDSC	ULK1_4989	11.865
SIDM00123	KIRC\|kidney	p.T309P (No)	GDSC	ULK1_4989	52.632
SIDM00920	BRCA\|breast	p.P574R (No)	GDSC	ULK1_4989	2.5972
SIDM00118	COREAD\|large_intestine	p.E73D (No)	GDSC	ULK1_4989	3.5371

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SPTKAVPSF

Degron related mutations and impact score

Drug responses associated with ULK1 mutations

All proteins holding degron of SPTKAVPSF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75385	Serine/threonine-protein kinase ULK1	DEG_COP1_1	623:631	SPTKAVPSF	COP1	0.9972	More...