DegronMD

Uniprot ID: O75385

Source protein: Serine/threonine-protein kinase ULK1

Source gene: ULK1

Class: DEG_SPOP_SBC_1

Location: 420:424

E3 ligase: SPOP

DEGRON score: 0.9904

ASA_SCORE: 81.6

COIL: 0.8708

CONS_SCORE: 0.2605

DSS_SCORE: 0.5892

HELIX: 0.0816

FCONS_SCORE: 0.828

RIG_SCORE: 0.5565

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P431L	TCGA-D3-A8GI	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P431L	DO50284	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P414S	TCGA-EE-A3J5	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1667
p.P414S	DO47331	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.G416C	TCGA-ER-A19P	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.2222
p.G416C	DO47623	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.S422Y	TCGA-FS-A1ZG	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.712
p.S422Y	DO37523	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.712
p.P412H	TCGA-FS-A1ZU	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1111
p.P412H	DO37723	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R417W	TCGA-XV-AAZW	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.25
p.R417W	DO219495	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.25
p.P414L	DO220891	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.V434I	DO233472	PRAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0556
p.A418T	SIDM00450	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.A418T	SIDM00061	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.A418T	SIDM00235	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.A418T	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.A418T	RCC10RGB	kidney	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.C426R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.C426R	ACH-000953	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	0.2778
p.C426R	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.A428T	ACH-001369	Ovarian Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.2222

Drug responses associated with ULK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00132	PAAD\|pancreas	p.T309P (No)	GDSC	ULK1_4989	5.3414
SIDM01079	SKCM\|melanoma	p.P592S (No)	GDSC	ULK1_4989	29.915
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T309P (No)	GDSC	ULK1_4989	1.3211
SIDM00402	BLCA\|bladder	p.P574R (No)	GDSC	ULK1_4989	5.9027
SIDM00951	LAML\|acute_myeloid_leukaemia	p.Q173* (No)	GDSC	ULK1_4989	1.7846
SIDM00970	BLCA\|bladder	p.S330A (No)	GDSC	ULK1_4989	0.1396
SIDM00572	STAD\|stomach	p.G530S (No)	GDSC	ULK1_4989	9.3725
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R137H (No)	GDSC	ULK1_4989	10.609
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T180I (No)	GDSC	ULK1_4989	10.609
SIDM01045	UCEC\|endometrium	p.A822fs*2 (No)	GDSC	ULK1_4989	4.6391
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.T575fs*72 (No)	GDSC	ULK1_4989	1.057
SIDM00145	ALL\|lymphoblastic_leukemia	p.A85V (No)	GDSC	ULK1_4989	4.2854
SIDM00145	ALL\|lymphoblastic_leukemia	p.Q640K (No)	GDSC	ULK1_4989	4.2854
SIDM00121	ALL\|lymphoblastic_leukemia	p.A728T (No)	GDSC	ULK1_4989	2.4991
SIDM00121	ALL\|lymphoblastic_leukemia	p.R959H (No)	GDSC	ULK1_4989	2.4991
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R153H (No)	GDSC	ULK1_4989	2.0135
SIDM00901	UCEC\|endometrium	p.S147P (No)	GDSC	ULK1_4989	3.1329
SIDM00272	BRCA\|breast	p.E320K (No)	GDSC	ULK1_4989	4.1939
SIDM00831	HNSC\|head_and_neck	p.T309P (No)	GDSC	ULK1_4989	3.7859
SIDM00964	UNCLASSIFIED\|prostate	p.T309P (No)	GDSC	ULK1_4989	3.204
SIDM00859	DLBC\|B_cell_lymphoma	p.A332T (No)	GDSC	ULK1_4989	4.3188
SIDM00785	LAML\|acute_myeloid_leukaemia	p.T850M (No)	GDSC	ULK1_4989	31.177
SIDM01048	MM\|lymphoid_neoplasm_other	p.G762R (No)	GDSC	ULK1_4989	3.461
SIDM01007	ALL\|lymphoblastic_leukemia	p.R697H (No)	GDSC	ULK1_4989	2.9575
SIDM00537	COREAD\|large_intestine	p.P481fs*166 (No)	GDSC	ULK1_4989	9.3085
SIDM00235	KIRC\|kidney	p.A418T (Yes)	GDSC	ULK1_4989	790.31
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.E73K (No)	GDSC	ULK1_4989	27.268
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.I620fs*27 (No)	GDSC	ULK1_4989	2.6755
SIDM01090	COREAD\|large_intestine	p.A711V (No)	GDSC	ULK1_4989	10.414
SIDM01020	MM\|myeloma	p.G301S (No)	GDSC	ULK1_4989	1.6816
SIDM00505	PAAD\|pancreas	p.A705V (No)	GDSC	ULK1_4989	5.366
SIDM00137	LUAD\|lung_NSCLC_adenocarcinoma	p.S310P (No)	GDSC	ULK1_4989	8.0359
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R553fs*92 (No)	GDSC	ULK1_4989	8.1576
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.Q965K (No)	GDSC	ULK1_4989	2.2765
SIDM00217	COREAD\|large_intestine	p.R266C (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.P435L (Yes)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.P634L (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.R697H (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.R845C (No)	GDSC	ULK1_4989	11.825
SIDM00217	COREAD\|large_intestine	p.S1042T (No)	GDSC	ULK1_4989	11.825
SIDM01083	HNSC\|head_and_neck	p.T309P (No)	GDSC	ULK1_4989	26.992
SIDM00280	UNCLASSIFIED\|stomach	p.S298L (No)	GDSC	ULK1_4989	7.2778
SIDM00839	COREAD\|large_intestine	p.R603W (No)	GDSC	ULK1_4989	67.4
SIDM00231	KIRC\|kidney	p.T309P (No)	GDSC	ULK1_4989	18.479
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N559K (No)	GDSC	ULK1_4989	6.5064
SIDM00150	COREAD\|large_intestine	p.P435L (Yes)	GDSC	ULK1_4989	908.87
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T309P (No)	GDSC	ULK1_4989	13.336
SIDM00587	UNCLASSIFIED\|biliary_tract	p.P714R (No)	GDSC	ULK1_4989	4.1074
SIDM00810	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R458G (No)	GDSC	ULK1_4989	6.9311
SIDM01189	GBM\|glioma	p.D700G (No)	GDSC	ULK1_4989	20.045
SIDM00257	NB\|neuroblastoma	p.A711V (No)	GDSC	ULK1_4989	7.9723
SIDM01205	DLBC\|B_cell_lymphoma	p.T309P (No)	GDSC	ULK1_4989	2.7822
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.T309P (No)	GDSC	ULK1_4989	55.606
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S317F (No)	GDSC	ULK1_4989	55.606
SIDM00273	LGG\|glioma	p.G762R (No)	GDSC	ULK1_4989	7.0212
SIDM00487	COREAD\|large_intestine	p.A125T (No)	GDSC	ULK1_4989	600.8
SIDM00282	COREAD\|large_intestine	p.Q767fs*35 (No)	GDSC	ULK1_4989	752.22
SIDM00114	MESO\|mesothelioma	p.K686M (No)	GDSC	ULK1_4989	257.45
SIDM00114	MESO\|mesothelioma	p.P805S (No)	GDSC	ULK1_4989	257.45
SIDM00241	BRCA\|breast	p.R691Q (No)	GDSC	ULK1_4989	0.9961
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.S784C (No)	GDSC	ULK1_4989	47.132
SIDM00541	COREAD\|large_intestine	p.E718D (No)	GDSC	ULK1_4989	6.2698
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.C426R (Yes)	GDSC	ULK1_4989	2.6777
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.V489I (No)	GDSC	ULK1_4989	48.352
SIDM00046	LUAD\|lung_NSCLC_adenocarcinoma	p.T309P (No)	GDSC	ULK1_4989	6.872
SIDM00834	COREAD\|large_intestine	p.R603Q (No)	GDSC	ULK1_4989	176.03
SIDM01259	ALL\|lymphoblastic_leukemia	p.P624S (No)	GDSC	ULK1_4989	5.9154
SIDM00457	MM\|myeloma	p.G762R (No)	GDSC	ULK1_4989	2.3387
SIDM00562	BRCA\|breast	p.D576N (No)	GDSC	ULK1_4989	11.865
SIDM00123	KIRC\|kidney	p.T309P (No)	GDSC	ULK1_4989	52.632
SIDM00920	BRCA\|breast	p.P574R (No)	GDSC	ULK1_4989	2.5972
SIDM00118	COREAD\|large_intestine	p.E73D (No)	GDSC	ULK1_4989	3.5371

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	78:82	PFSSS	SPOP	0.9307	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	941:945	PFSSS	SPOP	0.9991	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	527:531	PFSSS	SPOP	0.7804	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	466:470	PFSSS	SPOP	0.9364	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1803:1807	PFSSS	SPOP	0.6327	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with ULK1 mutations

All proteins holding degron of PFSSS