DegronMD - Q9BYP7(WNK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P906T	TCGA-21-1070	LUSC	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.0833
p.P906T	DO27088	LUSC	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.0833
p.P1076L	TCGA-21-1071	LUSC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation altering degron motif	0.6471
p.P1076L	DO26918	LUSC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation altering degron motif	0.6471
p.E537D	TCGA-31-1950	OV	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.6758
p.E537D	DO30980	OV	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.6758
p.S1146F	TCGA-55-8094	LUAD	TCGA	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7982
p.S1146F	DO24150	LUAD	ICGC	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7982
p.Q1088P	TCGA-93-A4JQ	LUAD	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.Q1088P	DO51195	LUAD	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.E1427K	TCGA-A1-A0SI	BRCA	TCGA	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.1667
p.E1427K	DO1774	BRCA	ICGC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.1667
p.I914T	TCGA-A3-A8CQ	KIRC	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.3056
p.I914T	DO49688	KIRC	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.3056
p.Q1088K	TCGA-AG-A00C	READ	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.S1140N	TCGA-AJ-A3EL	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.2222
p.S1140N	DO41542	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.2222
p.P1071L	TCGA-AO-A03N	BRCA	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.P1071L	DO5808	BRCA	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.E537A	TCGA-AP-A1E0	UCEC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7701
p.E537A	DO43154	UCEC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7701
p.S910I	TCGA-AX-A2HC	UCEC	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.1944
p.S910I	DO41572	UCEC	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.1944
p.T541A	TCGA-AZ-6605	COAD	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7139
p.T541A	DO8762	COAD	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7139
p.E537G	TCGA-B0-5092	KIRC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7199
p.E537G	DO20663	KIRC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7199
p.D544N	TCGA-BG-A222	UCEC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.6932
p.D544N	DO42977	UCEC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.6932
p.L919F	TCGA-BR-6802	STAD	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation altering degron motif	0.6981
p.L919F	DO38332	STAD	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation altering degron motif	0.6981
p.V1412A	TCGA-BR-8487	STAD	TCGA	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.2778
p.V1412A	DO47867	STAD	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.2778
p.E1440K	TCGA-C5-A7CJ	CESC	TCGA	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.2778
p.E1440K	DO49886	CESC	ICGC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.2778
p.L528V	TCGA-CR-6484	HNSC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.0833
p.L528V	DO15206	HNSC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.0833
p.G1411E	TCGA-D1-A16X	UCEC	TCGA	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.3056
p.G1411E	DO41799	UCEC	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.3056
p.P1080T	TCGA-DJ-A2QB	THCA	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation altering degron motif	0.7031
p.P1080T	DO39421	THCA	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation altering degron motif	0.7031
p.T534I	TCGA-DU-6392	LGG	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.25
p.T534I	DO22237	LGG	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.25
p.V543F	TCGA-DU-A6S7	LGG	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7068
p.V543F	DO50149	LGG	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation altering degron motif	0.7068
p.P1156S	TCGA-EE-A29D	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.1111
p.P1156S	DO38123	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.1111
p.P1071H	TCGA-EO-A22X	UCEC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.P1071H	DO43907	UCEC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.A1068S	TCGA-EO-A3AV	UCEC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1111
p.A1068S	DO52412	UCEC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1111
p.G1416C	TCGA-ER-A2NH	SKCM	TCGA	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1667
p.G1416C	DO47683	SKCM	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1667
p.G1416C	DO229253	THCA	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1667
p.F1419L	TCGA-EY-A1GI	UCEC	TCGA	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0833
p.F1419L	DO41211	UCEC	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0833
p.E1404D	TCGA-F5-6814	READ	TCGA	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.2778
p.E1404D	DO36556	READ	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.2778
p.G535V	TCGA-FS-A1Z0	SKCM	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.2778
p.G535V	DO37431	SKCM	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.2778
p.S1147F	TCGA-FW-A3R5	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7982
p.S1147F	DO37406	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7982
p.Q1088E	TCGA-HD-A4C1	HNSC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.Q1088E	DO44453	HNSC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1944
p.E1404Q	TCGA-OR-A5KB	ACC	TCGA	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.2778
p.P1084Q	TCGA-TM-A84G	LGG	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.3056
p.P1084Q	DO50232	LGG	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.3056
p.N925S	TCGA-V1-A9O5	PRAD	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.2778
p.N925S	DO219369	PRAD	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.2778
p.P1084S	TCGA-VS-A9UJ	CESC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.3056
p.P1084S	DO219735	CESC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.3056
p.R929H	DO222955	BTCA	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.1667
p.A930V	DO222973	BTCA	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.1389
p.T1158A	DO222798	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.0556
p.Q550P	DO50447	ESAD	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.2222
p.P8Q	DO229019	LICA	ICGC	DSGDPAS	DEG_SCF_TRCP1_1	4:10	Mutation altering degron motif	0.5924
p.T534N	DO229019	LICA	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.25
p.S1448R	DO229015	LICA	ICGC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.0556
p.P1435S	DO231047	LUSC	ICGC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation altering degron motif	0.6752
p.C1406Y	DO228435	MALY	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.5976
p.S1443L	DO220897	MELA	ICGC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.1944
p.P1435L	DO222527	MELA	ICGC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation altering degron motif	0.7582
p.E913K	DO222749	MELA	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation rewiring degron network	0.2778
p.S1070Y	DO232067	ORCA	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	1076:1083	Mutation rewiring degron network	0.1667
p.E1408K	DO32831	PACA	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.7022
p.G19R	DO232761	PBCA	ICGC	DSGDPAS	DEG_SCF_TRCP1_1	4:10	Mutation rewiring degron network	0.0833
p.Y1396H	DO229114	PRAD	ICGC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0556
p.R916W	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation altering degron motif	0.8634
p.R916W	T-T	oesophagus	COSMIC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation altering degron motif	0.8634
p.A2T	SIDM00216	Colorectal Carcinoma	GDSC	DSGDPAS	DEG_SCF_TRCP1_1	4:10	Mutation rewiring degron network	0.2778
p.A2T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGDPAS	DEG_SCF_TRCP1_1	4:10	Mutation rewiring degron network	0.2778
p.A2T	SNU-175	large intestine	COSMIC	DSGDPAS	DEG_SCF_TRCP1_1	4:10	Mutation rewiring degron network	0.2778
p.Q1135H	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.0833
p.Q1135H	ACH-000893	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.0833
p.Q1135H	NCI-H1651	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.0833
p.S905N	SIDM00841	Colorectal Carcinoma	GDSC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation blocking phosphorylation signal	0.5
p.S905N	SW620	large intestine	COSMIC	SRDTLLTIE	DEG_APCC_DBOX_1	915:923	Mutation blocking phosphorylation signal	0.5
p.A536T	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.3056
p.A536T	ACH-000109	Lung Cancer	CCLE	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.3056
p.A536T	H3255	lung	COSMIC	ECEETEVDQH	DEG_Kelch_KLHL3_1	537:546	Mutation rewiring degron network	0.3056
p.E1397D	ACH-001796	Liposarcoma	CCLE	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0833
p.S1423R	JHH-2	liver	COSMIC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.0556
p.A1430S	NCI-H1417	lung	COSMIC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.25
p.S1404F	SISO	cervix	COSMIC	CKENK	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.2778
p.A1440V	SNU-1040	large intestine	COSMIC	VTPEKE	DEG_SCF_FBW7_2	1433:1438	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WNK3

UniProt ID: Q9BYP7

Entrez ID: 65267

Protein name: Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WNK3 in