DegronMD

Uniprot ID: Q9BYP7

Source protein: Serine/threonine-protein kinase WNK3

Source gene: WNK3

Class: DEG_Kelch_KLHL3_1

Location: 537:546

E3 ligase: CUL3,KLHL3,KLHL2

DEGRON score: 0.9556

ASA_SCORE: 97.01

COIL: 0.5287

CONS_SCORE: 0.4329

DSS_SCORE: 0.5242

HELIX: 0.4319

FCONS_SCORE: 1.0708

RIG_SCORE: 0.7558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E537D	TCGA-31-1950	OV	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.6758
p.E537D	DO30980	OV	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.6758
p.E537A	TCGA-AP-A1E0	UCEC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7701
p.E537A	DO43154	UCEC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7701
p.T541A	TCGA-AZ-6605	COAD	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7139
p.T541A	DO8762	COAD	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7139
p.E537G	TCGA-B0-5092	KIRC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7199
p.E537G	DO20663	KIRC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7199
p.D544N	TCGA-BG-A222	UCEC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.6932
p.D544N	DO42977	UCEC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.6932
p.L528V	TCGA-CR-6484	HNSC	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.0833
p.L528V	DO15206	HNSC	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.0833
p.T534I	TCGA-DU-6392	LGG	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.25
p.T534I	DO22237	LGG	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.25
p.V543F	TCGA-DU-A6S7	LGG	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7068
p.V543F	DO50149	LGG	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.7068
p.G535V	TCGA-FS-A1Z0	SKCM	TCGA	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.2778
p.G535V	DO37431	SKCM	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.2778
p.Q550P	DO50447	ESAD	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.2222
p.T534N	DO229019	LICA	ICGC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.25
p.A536T	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.3056
p.A536T	ACH-000109	Lung Cancer	CCLE	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.3056
p.A536T	H3255	lung	COSMIC	ECEETEVDQH	DEG_Kelch_KLHL3_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_Kelch_KLHL3_1	537:546	ECEETEVDQH	CUL3,KLHL3,KLHL2	0.9556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons