DegronMD

Uniprot ID: Q9BYP7

Source protein: Serine/threonine-protein kinase WNK3

Source gene: WNK3

Class: DEG_SCF_TRCP1_1

Location: 4:10

E3 ligase: BTRC

DEGRON score: 0.9757

ASA_SCORE: 67.2429

COIL: 0.8907

CONS_SCORE: 0.4456

DSS_SCORE: 0.9139

HELIX: 0.0707

FCONS_SCORE: 1.0365

RIG_SCORE: 0.5853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P8Q	DO229019	LICA	ICGC	DSGDPAS	DEG_SCF_TRCP1_1	0.5924
p.G19R	DO232761	PBCA	ICGC	DSGDPAS	DEG_SCF_TRCP1_1	0.0833
p.A2T	SIDM00216	Colorectal Carcinoma	GDSC	DSGDPAS	DEG_SCF_TRCP1_1	0.2778
p.A2T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGDPAS	DEG_SCF_TRCP1_1	0.2778
p.A2T	SNU-175	large_intestine	COSMIC	DSGDPAS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SCF_TRCP1_1	4:10	DSGDPAS	BTRC	0.9757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons