DegronMD

Uniprot ID: Q9BYP7

Source protein: Serine/threonine-protein kinase WNK3

Source gene: WNK3

Class: DEG_APCC_KENBOX_2

Location: 1406:1410

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5523

ASA_SCORE: 108.88

COIL: 0.7316

CONS_SCORE: 0.3903

DSS_SCORE: 0.4504

HELIX: 0.203

FCONS_SCORE: 0.9717

RIG_SCORE: 0.7478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1412A	TCGA-BR-8487	STAD	TCGA	CKENK	DEG_APCC_KENBOX_2	0.2778
p.V1412A	DO47867	STAD	ICGC	CKENK	DEG_APCC_KENBOX_2	0.2778
p.G1411E	TCGA-D1-A16X	UCEC	TCGA	CKENK	DEG_APCC_KENBOX_2	0.3056
p.G1411E	DO41799	UCEC	ICGC	CKENK	DEG_APCC_KENBOX_2	0.3056
p.G1416C	TCGA-ER-A2NH	SKCM	TCGA	CKENK	DEG_APCC_KENBOX_2	0.1667
p.G1416C	DO47683	SKCM	ICGC	CKENK	DEG_APCC_KENBOX_2	0.1667
p.G1416C	DO229253	THCA	ICGC	CKENK	DEG_APCC_KENBOX_2	0.1667
p.F1419L	TCGA-EY-A1GI	UCEC	TCGA	CKENK	DEG_APCC_KENBOX_2	0.0833
p.F1419L	DO41211	UCEC	ICGC	CKENK	DEG_APCC_KENBOX_2	0.0833
p.E1404D	TCGA-F5-6814	READ	TCGA	CKENK	DEG_APCC_KENBOX_2	0.2778
p.E1404D	DO36556	READ	ICGC	CKENK	DEG_APCC_KENBOX_2	0.2778
p.E1404Q	TCGA-OR-A5KB	ACC	TCGA	CKENK	DEG_APCC_KENBOX_2	0.2778
p.C1406Y	DO228435	MALY	ICGC	CKENK	DEG_APCC_KENBOX_2	0.5976
p.E1408K	DO32831	PACA	ICGC	CKENK	DEG_APCC_KENBOX_2	0.7022
p.Y1396H	DO229114	PRAD	ICGC	CKENK	DEG_APCC_KENBOX_2	0.0556
p.E1397D	ACH-001796	Liposarcoma	CCLE	CKENK	DEG_APCC_KENBOX_2	0.0833
p.S1404F	SISO	cervix	COSMIC	CKENK	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_APCC_KENBOX_2	1406:1410	CKENK	APC,CDC20,FZR1	0.5523	More...
A3KN83	Protein strawberry notch homolog 1	DEG_APCC_KENBOX_2	699:703	CKENK	APC,CDC20,FZR1	0.8367	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons