DegronMD - A3KN83(SBNO1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D684N	TCGA-06-5416	GBM	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.D684N	TCGA-A5-A0G2	UCEC	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.D684N	DO10880	GBM	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.D684N	DO41235	UCEC	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.D684N	SIDM00396	Acute Myeloid Leukemia	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.D684N	SIDM01123	Prostate Carcinoma	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.D684N	SIDM01504	Small Cell Lung Carcinoma	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.T85S	TCGA-2G-AAGK	TGCT	TCGA	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.6005
p.L841F	TCGA-66-2785	LUSC	TCGA	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation rewiring degron network	0.1111
p.L841F	DO26520	LUSC	ICGC	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation rewiring degron network	0.1111
p.E744K	TCGA-77-8136	LUSC	TCGA	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.1389
p.E744K	DO26593	LUSC	ICGC	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.1389
p.R1157Q	TCGA-A5-A0GB	UCEC	TCGA	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation rewiring degron network	0.1111
p.R1157Q	DO41434	UCEC	ICGC	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation rewiring degron network	0.1111
p.P763Q	TCGA-AC-A23H	BRCA	TCGA	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation altering degron motif	0.7035
p.P763Q	DO2401	BRCA	ICGC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation altering degron motif	0.7035
p.S693L	TCGA-AG-A002	READ	TCGA	CKENK	DEG_APCC_KENBOX_2	699:703	Mutation blocking phosphorylation signal	0.6111
p.S693L	TCGA-E6-A1LX	UCEC	TCGA	CKENK	DEG_APCC_KENBOX_2	699:703	Mutation blocking phosphorylation signal	0.6111
p.S693L	DO41020	UCEC	ICGC	CKENK	DEG_APCC_KENBOX_2	699:703	Mutation blocking phosphorylation signal	0.6111
p.N77H	TCGA-AX-A0J0	UCEC	TCGA	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.N77H	DO41133	UCEC	ICGC	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.N742S	TCGA-BQ-7059	KIRP	TCGA	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.1944
p.N742S	DO20932	KIRP	ICGC	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.1944
p.L1165M	TCGA-BS-A0UV	UCEC	TCGA	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation altering degron motif	0.5999
p.L1165M	DO229026	LICA	ICGC	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation altering degron motif	0.5999
p.L1165M	DO42793	UCEC	ICGC	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation altering degron motif	0.5999
p.Y747C	TCGA-CG-5721	STAD	TCGA	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.0556
p.Y747C	DO38192	STAD	ICGC	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.0556
p.P1167L	TCGA-D1-A17U	UCEC	TCGA	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation altering degron motif	0.7582
p.P1167L	DO41887	UCEC	ICGC	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation altering degron motif	0.7582
p.R707L	TCGA-D3-A2JP	SKCM	TCGA	CKENK	DEG_APCC_KENBOX_2	699:703	Mutation rewiring degron network	0.2222
p.R707L	DO47407	SKCM	ICGC	CKENK	DEG_APCC_KENBOX_2	699:703	Mutation rewiring degron network	0.2222
p.G723S	TCGA-D3-A51R	SKCM	TCGA	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.0833
p.G723S	DO47480	SKCM	ICGC	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.0833
p.P820Q	TCGA-DA-A1I7	SKCM	TCGA	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation rewiring degron network	0.1667
p.P820Q	DO37951	SKCM	ICGC	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation rewiring degron network	0.1667
p.D27H	TCGA-DK-AA75	BLCA	TCGA	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.1667
p.D27H	DO219012	BLCA	ICGC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.1667
p.P776L	TCGA-EE-A2A2	SKCM	TCGA	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation rewiring degron network	0.0556
p.P776L	DO37583	SKCM	ICGC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation rewiring degron network	0.0556
p.P672Q	TCGA-EE-A2MM	SKCM	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.3056
p.P672Q	DO37770	SKCM	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.3056
p.P97T	TCGA-FJ-A3Z7	BLCA	TCGA	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.1111
p.P97T	DO463	BLCA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.1111
p.P688S	TCGA-FR-A726	SKCM	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1389
p.P688S	DO48665	SKCM	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1389
p.S768C	TCGA-YC-A9TC	BLCA	TCGA	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation blocking phosphorylation signal	0.7222
p.S768C	DO51949	BLCA	ICGC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation blocking phosphorylation signal	0.7222
p.S768C	SIDM00485	Oral Cavity Carcinoma	GDSC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation blocking phosphorylation signal	0.7222
p.S768C	ACH-000794	Head and Neck Cancer	CCLE	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation blocking phosphorylation signal	0.7222
p.S768C	BICR22	upper aerodigestive tract	COSMIC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation blocking phosphorylation signal	0.7222
p.P1167R	DO222483	BTCA	ICGC	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation altering degron motif	0.7512
p.A74V	DO222427	BTCA	ICGC	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1111
p.S45L	DO222957	BTCA	ICGC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.1667
p.L120S	DO229359	BTCA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.1111
p.P38H	DO228092	EOPC	ICGC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation altering degron motif	0.6583
p.G724D	DO233869	GACA	ICGC	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.1111
p.P36T	DO228939	LICA	ICGC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation altering degron motif	0.7031
p.A739D	DO228948	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.2778
p.T121N	DO228986	LICA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.0833
p.D731E	DO229019	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	732:737	Mutation rewiring degron network	0.3056
p.P98H	DO229025	LICA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.1389
p.L677I	DO229027	LICA	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.7174
p.N752K	DO229027	LICA	ICGC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation rewiring degron network	0.0833
p.Q92K	DO229026	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.P38T	DO229031	LICA	ICGC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation altering degron motif	0.5919
p.H668N	DO229036	LICA	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1944
p.P73Q	DO229009	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.N114K	DO231652	LINC	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.2778
p.T686P	DO23516	LIRI	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation blocking phosphorylation signal	0.6389
p.P698L	DO222647	MELA	ICGC	CKENK	DEG_APCC_KENBOX_2	699:703	Mutation rewiring degron network	0.3056
p.P694L	DO222653	MELA	ICGC	CKENK	DEG_APCC_KENBOX_2	699:703	Mutation rewiring degron network	0.1944
p.N769D	SIDM00396	Acute Myeloid Leukemia	GDSC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation rewiring degron network	0.25
p.N769D	ACH-000112	Leukemia	CCLE	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation rewiring degron network	0.25
p.N769D	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation rewiring degron network	0.25
p.P40L	SIDM01151	Hepatocellular Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.3056
p.P40L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.3056
p.P40L	SIDM00164	Biliary Tract Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.3056
p.I26V	SIDM00845	Burkitt's Lymphoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.1389
p.I26V	SIDM01519	Head and Neck Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.1389
p.S817P	SIDM00193	Colorectal Carcinoma	GDSC	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation blocking phosphorylation signal	0.5278
p.S817P	ACH-000991	Colon/Colorectal Cancer	CCLE	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation blocking phosphorylation signal	0.5278
p.S817P	SNU-81	large intestine	COSMIC	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation blocking phosphorylation signal	0.5278
p.S1159N	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation rewiring degron network	0.1667
p.S41L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.2778
p.S41L	ACH-000878	Lung Cancer	CCLE	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.2778
p.S41L	HCC-15	lung	COSMIC	LATPMPT	DEG_SCF_FBW7_1	33:39	Mutation rewiring degron network	0.2778
p.P110L	SIDM00125	Kidney Carcinoma	GDSC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.6471
p.P110L	ACH-000649	Kidney Cancer	CCLE	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.6471
p.P110L	786-0	kidney	COSMIC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.6471
p.R79S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R79S	NCI-H1793	lung	COSMIC	PPSTT	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.K1163E	SIDM01611	Endometrial Carcinoma	GDSC	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation rewiring degron network	0.2778
p.K1163E	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTPGYS	DEG_SCF_FBW7_1	1165:1170	Mutation rewiring degron network	0.2778
p.P670S	SIDM01782	Oral Cavity Carcinoma	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.P670S	ACH-000723	Head and Neck Cancer	CCLE	DRKKLYSLL	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.S767C	BICR22	upper aerodigestive tract	COSMIC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation rewiring degron network	0.3056
p.S816P	SNU-81	large intestine	COSMIC	PNSTPANS	DEG_SCF_FBW7_1	826:833	Mutation rewiring degron network	0.0556
p.N768D	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	FNPFLD	LIG_APCC_ABBA_1	761:766	Mutation blocking phosphorylation signal	0.7222
p.P109L	786-0	kidney	COSMIC	MTKTPPVT	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SBNO1

UniProt ID: A3KN83

Entrez ID: 55206

Protein name: Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SBNO1 in