DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: DEG_APCC_DBOX_1

Location: 673:681

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7424

ASA_SCORE: 81.7

COIL: 0.5604

CONS_SCORE: 0.3574

DSS_SCORE: 0.3238

HELIX: 0.3031

FCONS_SCORE: 0.8589

RIG_SCORE: 0.7994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D684N	TCGA-06-5416	GBM	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.D684N	TCGA-A5-A0G2	UCEC	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.D684N	DO10880	GBM	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.D684N	DO41235	UCEC	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.D684N	SIDM00396	Acute Myeloid Leukemia	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.D684N	SIDM01123	Prostate Carcinoma	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.D684N	SIDM01504	Small Cell Lung Carcinoma	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.P672Q	TCGA-EE-A2MM	SKCM	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	0.3056
p.P672Q	DO37770	SKCM	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	0.3056
p.P688S	TCGA-FR-A726	SKCM	TCGA	DRKKLYSLL	DEG_APCC_DBOX_1	0.1389
p.P688S	DO48665	SKCM	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	0.1389
p.L677I	DO229027	LICA	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	0.7174
p.H668N	DO229036	LICA	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	0.1944
p.T686P	DO23516	LIRI	ICGC	DRKKLYSLL	DEG_APCC_DBOX_1	0.6389
p.P670S	SIDM01782	Oral Cavity Carcinoma	GDSC	DRKKLYSLL	DEG_APCC_DBOX_1	0.25
p.P670S	ACH-000723	Head and Neck Cancer	CCLE	DRKKLYSLL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KN83	Protein strawberry notch homolog 1	DEG_APCC_DBOX_1	673:681	DRKKLYSLL	APC,CDC20,FZR1	0.7424	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons