DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: DEG_SCF_FBW7_1

Location: 1165:1170

E3 ligase: FBXW7

DEGRON score: 0.9814

ASA_SCORE: 56.6667

COIL: 0.8115

CONS_SCORE: 0.3193

DSS_SCORE: 0.2909

HELIX: 0.0438

FCONS_SCORE: 0.8571

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1157Q	TCGA-A5-A0GB	UCEC	TCGA	LTPGYS	DEG_SCF_FBW7_1	0.1111
p.R1157Q	DO41434	UCEC	ICGC	LTPGYS	DEG_SCF_FBW7_1	0.1111
p.L1165M	TCGA-BS-A0UV	UCEC	TCGA	LTPGYS	DEG_SCF_FBW7_1	0.5999
p.L1165M	DO229026	LICA	ICGC	LTPGYS	DEG_SCF_FBW7_1	0.5999
p.L1165M	DO42793	UCEC	ICGC	LTPGYS	DEG_SCF_FBW7_1	0.5999
p.P1167L	TCGA-D1-A17U	UCEC	TCGA	LTPGYS	DEG_SCF_FBW7_1	0.7582
p.P1167L	DO41887	UCEC	ICGC	LTPGYS	DEG_SCF_FBW7_1	0.7582
p.P1167R	DO222483	BTCA	ICGC	LTPGYS	DEG_SCF_FBW7_1	0.7512
p.S1159N	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	LTPGYS	DEG_SCF_FBW7_1	0.1667
p.K1163E	SIDM01611	Endometrial Carcinoma	GDSC	LTPGYS	DEG_SCF_FBW7_1	0.2778
p.K1163E	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTPGYS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KN83	Protein strawberry notch homolog 1	DEG_SCF_FBW7_1	1165:1170	LTPGYS	FBXW7	0.9814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons