DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: DEG_SCF_FBW7_1

Location: 105:112

E3 ligase: FBXW7

DEGRON score: 0.9812

ASA_SCORE: 86.125

COIL: 0.8326

CONS_SCORE: 0.2562

DSS_SCORE: 0.4872

HELIX: 0.0166

FCONS_SCORE: 0.8676

RIG_SCORE: 0.7752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P97T	TCGA-FJ-A3Z7	BLCA	TCGA	MTKTPPVT	DEG_SCF_FBW7_1	0.1111
p.P97T	DO463	BLCA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	0.1111
p.L120S	DO229359	BTCA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	0.1111
p.T121N	DO228986	LICA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	0.0833
p.P98H	DO229025	LICA	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	0.1389
p.N114K	DO231652	LINC	ICGC	MTKTPPVT	DEG_SCF_FBW7_1	0.2778
p.P110L	SIDM00125	Kidney Carcinoma	GDSC	MTKTPPVT	DEG_SCF_FBW7_1	0.6471
p.P110L	ACH-000649	Kidney Cancer	CCLE	MTKTPPVT	DEG_SCF_FBW7_1	0.6471
p.P110L	786-0	kidney	COSMIC	MTKTPPVT	DEG_SCF_FBW7_1	0.6471
p.P109L	786-0	kidney	COSMIC	MTKTPPVT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KN83	Protein strawberry notch homolog 1	DEG_SCF_FBW7_1	105:112	MTKTPPVT	FBXW7	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons