DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: DEG_SCF_TRCP1_1

Location: 732:737

E3 ligase: BTRC

DEGRON score: 0.9559

ASA_SCORE: 79.8333

COIL: 0.87

CONS_SCORE: 0.3246

DSS_SCORE: 0.744

HELIX: 0.0965

FCONS_SCORE: 1.0432

RIG_SCORE: 0.5175

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E744K	TCGA-77-8136	LUSC	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.1389
p.E744K	DO26593	LUSC	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1389
p.N742S	TCGA-BQ-7059	KIRP	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.N742S	DO20932	KIRP	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.Y747C	TCGA-CG-5721	STAD	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.0556
p.Y747C	DO38192	STAD	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.0556
p.G723S	TCGA-D3-A51R	SKCM	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.G723S	DO47480	SKCM	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.G724D	DO233869	GACA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1111
p.A739D	DO228948	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.2778
p.D731E	DO229019	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14646	Chromodomain-helicase-DNA-binding protein 1	DEG_SCF_TRCP1_1	53:58	DSGSES	BTRC	0.9873	More...
Q96MU7	YTH domain-containing protein 1	DEG_SCF_TRCP1_1	272:277	DSGSES	BTRC	0.951	More...
A3KN83	Protein strawberry notch homolog 1	DEG_SCF_TRCP1_1	732:737	DSGSES	BTRC	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons