DegronMD

Uniprot ID: Q96MU7

Source protein: YTH domain-containing protein 1

Source gene: YTHDC1

Class: DEG_SCF_TRCP1_1

Location: 272:277

E3 ligase: BTRC

DEGRON score: 0.951

ASA_SCORE: 88.9

COIL: 0.9292

CONS_SCORE: 0.2775

DSS_SCORE: 0.6887

HELIX: 0.0542

FCONS_SCORE: 0.8416

RIG_SCORE: 0.5467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R267Q	TCGA-AA-3984	COAD	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.R267Q	TCGA-AG-A002	READ	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.R267Q	TCGA-EO-A22X	UCEC	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.R267Q	DO9002	COAD	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.R267Q	DO43907	UCEC	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.D263G	TCGA-AA-A00N	COAD	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.D263G	DO9876	COAD	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.D263Y	TCGA-AP-A056	UCEC	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.D263Y	DO43971	UCEC	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.D282Y	TCGA-AX-A2HC	UCEC	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.D282Y	DO224600	BRCA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.D282Y	DO1011	BRCA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.D282Y	DO41572	UCEC	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.1944
p.Y264C	TCGA-IS-A3K8	SARC	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.5556
p.Y264C	DO220170	SARC	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.5556
p.S271G	TCGA-UY-A9PB	BLCA	TCGA	DSGSES	DEG_SCF_TRCP1_1	0.3056
p.S271G	DO219041	BLCA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.3056
p.D272V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DSGSES	DEG_SCF_TRCP1_1	0.7785
p.D272V	ACH-000917	Esophageal Cancer	CCLE	DSGSES	DEG_SCF_TRCP1_1	0.7785
p.D272V	TE-4	oesophagus	COSMIC	DSGSES	DEG_SCF_TRCP1_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14646	Chromodomain-helicase-DNA-binding protein 1	DEG_SCF_TRCP1_1	53:58	DSGSES	BTRC	0.9873	More...
Q96MU7	YTH domain-containing protein 1	DEG_SCF_TRCP1_1	272:277	DSGSES	BTRC	0.951	More...
A3KN83	Protein strawberry notch homolog 1	DEG_SCF_TRCP1_1	732:737	DSGSES	BTRC	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons