DegronMD - O14646(CHD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1656S	TCGA-A5-A1OF	UCEC	TCGA	DYR	CBL_MET	1657:1659	Mutation rewiring degron network	0.3056
p.R1656S	DO42568	UCEC	ICGC	DYR	CBL_MET	1657:1659	Mutation rewiring degron network	0.3056
p.S20L	TCGA-BR-4184	STAD	TCGA	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.25
p.S20L	DO38328	STAD	ICGC	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.25
p.S20L	ACH-001369	Ovarian Cancer	CCLE	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.25
p.G951C	TCGA-C5-A1MP	CESC	TCGA	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.2778
p.G951C	DO48980	CESC	ICGC	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.2778
p.S36C	TCGA-E9-A229	BRCA	TCGA	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111
p.S36C	DO5898	BRCA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111
p.R1656M	TCGA-EE-A29L	SKCM	TCGA	DYR	CBL_MET	1657:1659	Mutation rewiring degron network	0.3056
p.R1656M	DO37835	SKCM	ICGC	DYR	CBL_MET	1657:1659	Mutation rewiring degron network	0.3056
p.T958A	TCGA-EY-A215	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	953:957	Mutation blocking phosphorylation signal	0.75
p.T958A	DO42665	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	953:957	Mutation blocking phosphorylation signal	0.75
p.D1657G	TCGA-NA-A4R1	UCS	TCGA	DYR	CBL_MET	1657:1659	Mutation altering degron motif	0.7198
p.G33V	DO222537	BTCA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1944
p.S36Y	DO228948	LICA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111
p.S18R	DO229019	LICA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1944
p.D67E	DO229029	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	53:58	Mutation rewiring degron network	0.0833
p.D67E	DO229037	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	53:58	Mutation rewiring degron network	0.0833
p.T1650K	DO229038	LICA	ICGC	DYR	CBL_MET	1657:1659	Mutation rewiring degron network	0.1389
p.E964K	DO230536	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.1389
p.S54C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGSES	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.7541
p.S54C	ACH-001669	Leukemia	CCLE	DSGSES	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.7541
p.S54C	ACH-002238	Leukemia	CCLE	DSGSES	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.7541
p.S54C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DSGSES	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.7541
p.T943I	SIDM01194	Hepatocellular Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.T943I	ACH-000420	Liver Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.T943I	SNU-449	liver	COSMIC	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.T943S	SIDM00282	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.T943S	ACH-000998	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.T943S	CW-2	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556

Kaplan plot for CHD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD1

UniProt ID: O14646

Entrez ID: 1105

Protein name: Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD1 in