DegronMD

Uniprot ID: O14646

Source protein: Chromodomain-helicase-DNA-binding protein 1

Source gene: CHD1

Class: DEG_SCF_TRCP1_1

Location: 23:28

E3 ligase: BTRC

DEGRON score: 0.8195

ASA_SCORE: 88.2167

COIL: 0.9678

CONS_SCORE: 0.2342

DSS_SCORE: 0.7691

HELIX: 0.0255

FCONS_SCORE: 1.0023

RIG_SCORE: 0.4687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S20L	TCGA-BR-4184	STAD	TCGA	DSGSAS	DEG_SCF_TRCP1_1	0.25
p.S20L	DO38328	STAD	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.25
p.S20L	ACH-001369	Ovarian Cancer	CCLE	DSGSAS	DEG_SCF_TRCP1_1	0.25
p.S36C	TCGA-E9-A229	BRCA	TCGA	DSGSAS	DEG_SCF_TRCP1_1	0.1111
p.S36C	DO5898	BRCA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.1111
p.G33V	DO222537	BTCA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.1944
p.S36Y	DO228948	LICA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.1111
p.S18R	DO229019	LICA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14646	Chromodomain-helicase-DNA-binding protein 1	DEG_SCF_TRCP1_1	23:28	DSGSAS	BTRC	0.8195	More...
O95361	Tripartite motif-containing protein 16	DEG_SCF_TRCP1_1	33:38	DSGSAS	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons