DegronMD - O95361(TRIM16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E41K	DO10204	COAD	ICGC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation rewiring degron network	0.0556
p.E41K	DO10204	COAD	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation rewiring degron network	0.25
p.R38Q	DO234150	ESAD	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation altering degron motif	0.7329
p.A21S	DO229029	LICA	ICGC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation rewiring degron network	0.1944
p.S24N	DO50970	LICA	ICGC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation blocking phosphorylation signal	0.7222
p.S24N	DO50970	LICA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation blocking phosphorylation signal	0.5278
p.E22D	DO26230	LUAD	ICGC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation rewiring degron network	0.2222
p.L19F	DO220906	MELA	ICGC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation rewiring degron network	0.1389
p.A32G	DO28000	OV	ICGC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation rewiring degron network	0.3056
p.A32G	DO28000	OV	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation rewiring degron network	0.3056
p.S36L	DO219984	SARC	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation altering degron motif	0.6556
p.G34C	DO37961	SKCM	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation altering degron motif	0.76
p.G34C	DO47509	SKCM	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation altering degron motif	0.76
p.E45K	DO43306	UCEC	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation rewiring degron network	0.1389
p.E45D	DO41572	UCEC	ICGC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation rewiring degron network	0.1389
p.S48A	SIDM01611	Endometrial Carcinoma	GDSC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation rewiring degron network	0.0556
p.L28V	Ca-Ski	cervix	COSMIC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation altering degron motif	0.6765
p.M46I	VMRC-RCW	kidney	COSMIC	DSGSAS	DEG_SCF_TRCP1_1	33:38	Mutation rewiring degron network	0.1111
p.P20S	C-33-A	cervix	COSMIC	DSGSPS	DEG_SCF_TRCP1_1	26:31	Mutation rewiring degron network	0.1667

Kaplan plot for TRIM16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM16

UniProt ID: O95361

Entrez ID: 10626

Protein name: Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM16 in