DegronMD

Uniprot ID: O95361

Source protein: Tripartite motif-containing protein 16

Source gene: TRIM16

Class: DEG_SCF_TRCP1_1

Location: 26:31

E3 ligase: BTRC

DEGRON score: 0.9717

ASA_SCORE: 67.9

COIL: 0.8547

CONS_SCORE: 0.3368

DSS_SCORE: 0.8668

HELIX: 0.0198

FCONS_SCORE: 0.4639

RIG_SCORE: 0.4219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E41K	DO10204	COAD	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.0556
p.A21S	DO229029	LICA	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.1944
p.S24N	DO50970	LICA	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.7222
p.E22D	DO26230	LUAD	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.2222
p.L19F	DO220906	MELA	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.1389
p.A32G	DO28000	OV	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.3056
p.L28V	Ca-Ski	cervix	COSMIC	DSGSPS	DEG_SCF_TRCP1_1	0.6765
p.P20S	C-33-A	cervix	COSMIC	DSGSPS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95361	Tripartite motif-containing protein 16	DEG_SCF_TRCP1_1	26:31	DSGSPS	BTRC	0.9717	More...
P43361	Melanoma-associated antigen 8	DEG_SCF_TRCP1_1	55:60	DSGSPS	BTRC	0.9504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons