DegronMD

Uniprot ID: P43361

Source protein: Melanoma-associated antigen 8

Source gene: MAGEA8

Class: DEG_SCF_TRCP1_1

Location: 55:60

E3 ligase: BTRC

DEGRON score: 0.9504

ASA_SCORE: 74.95

COIL: 0.965

CONS_SCORE: 0.2577

DSS_SCORE: 0.7993

HELIX: 0.014

FCONS_SCORE: 0.9553

RIG_SCORE: 0.533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L50I	TCGA-05-4389	LUAD	TCGA	DSGSPS	DEG_SCF_TRCP1_1	0.1944
p.L50I	DO24307	LUAD	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.1944
p.S56Y	TCGA-A5-A0G1	UCEC	TCGA	DSGSPS	DEG_SCF_TRCP1_1	0.712
p.S56Y	DO42472	UCEC	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.712
p.G48E	TCGA-EE-A2GI	SKCM	TCGA	DSGSPS	DEG_SCF_TRCP1_1	0.1389
p.G48E	DO37410	SKCM	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.1389
p.P62L	TCGA-EO-A3B0	UCEC	TCGA	DSGSPS	DEG_SCF_TRCP1_1	0.2778
p.P62L	DO219773	UCEC	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.2778
p.G48R	TCGA-FI-A2D0	UCEC	TCGA	DSGSPS	DEG_SCF_TRCP1_1	0.1389
p.G48R	DO43891	UCEC	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.1389
p.L45Q	DO48413	BLCA	ICGC	DSGSPS	DEG_SCF_TRCP1_1	0.0556
p.A68V	SIDM00974	Melanoma	GDSC	DSGSPS	DEG_SCF_TRCP1_1	0.1111
p.M47V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGSPS	DEG_SCF_TRCP1_1	0.1111
p.M47V	ACH-000937	Leukemia	CCLE	DSGSPS	DEG_SCF_TRCP1_1	0.1111
p.M47V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSPS	DEG_SCF_TRCP1_1	0.1111
p.S69P	ACH-001991	Primary	CCLE	DSGSPS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95361	Tripartite motif-containing protein 16	DEG_SCF_TRCP1_1	26:31	DSGSPS	BTRC	0.9717	More...
P43361	Melanoma-associated antigen 8	DEG_SCF_TRCP1_1	55:60	DSGSPS	BTRC	0.9504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons