DegronMD

Uniprot ID: O95361

Source protein: Tripartite motif-containing protein 16

Source gene: TRIM16

Class: DEG_SCF_TRCP1_1

Location: 33:38

E3 ligase: BTRC

DEGRON score: 0.9986

ASA_SCORE: 62.2167

COIL: 0.7842

CONS_SCORE: 0.788

DSS_SCORE: 0.8991

HELIX: 0.09

FCONS_SCORE: 1.3883

RIG_SCORE: 0.4383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E41K	DO10204	COAD	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.25
p.R38Q	DO234150	ESAD	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.7329
p.S24N	DO50970	LICA	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.5278
p.A32G	DO28000	OV	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.3056
p.S36L	DO219984	SARC	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.6556
p.G34C	DO37961	SKCM	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.76
p.G34C	DO47509	SKCM	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.76
p.E45K	DO43306	UCEC	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.1389
p.E45D	DO41572	UCEC	ICGC	DSGSAS	DEG_SCF_TRCP1_1	0.1389
p.S48A	SIDM01611	Endometrial Carcinoma	GDSC	DSGSAS	DEG_SCF_TRCP1_1	0.0556
p.M46I	VMRC-RCW	kidney	COSMIC	DSGSAS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14646	Chromodomain-helicase-DNA-binding protein 1	DEG_SCF_TRCP1_1	23:28	DSGSAS	BTRC	0.8195	More...
O95361	Tripartite motif-containing protein 16	DEG_SCF_TRCP1_1	33:38	DSGSAS	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons