DegronMD

Uniprot ID: O14646

Source protein: Chromodomain-helicase-DNA-binding protein 1

Source gene: CHD1

Class: DEG_SCF_TRCP1_1

Location: 53:58

E3 ligase: BTRC

DEGRON score: 0.9873

ASA_SCORE: 96.65

COIL: 0.9603

CONS_SCORE: 0.2838

DSS_SCORE: 0.7798

HELIX: 0.0293

FCONS_SCORE: 1.1911

RIG_SCORE: 0.4106

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D67E	DO229029	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.D67E	DO229037	LICA	ICGC	DSGSES	DEG_SCF_TRCP1_1	0.0833
p.S54C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGSES	DEG_SCF_TRCP1_1	0.7541
p.S54C	ACH-001669	Leukemia	CCLE	DSGSES	DEG_SCF_TRCP1_1	0.7541
p.S54C	ACH-002238	Leukemia	CCLE	DSGSES	DEG_SCF_TRCP1_1	0.7541
p.S54C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSES	DEG_SCF_TRCP1_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14646	Chromodomain-helicase-DNA-binding protein 1	DEG_SCF_TRCP1_1	53:58	DSGSES	BTRC	0.9873	More...
Q96MU7	YTH domain-containing protein 1	DEG_SCF_TRCP1_1	272:277	DSGSES	BTRC	0.951	More...
A3KN83	Protein strawberry notch homolog 1	DEG_SCF_TRCP1_1	732:737	DSGSES	BTRC	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons