DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: DEG_SCF_FBW7_1

Location: 33:39

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 69.4429

COIL: 0.912

CONS_SCORE: 0.2789

DSS_SCORE: 0.5773

HELIX: 0.0401

FCONS_SCORE: 0.9852

RIG_SCORE: 0.6701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D27H	TCGA-DK-AA75	BLCA	TCGA	LATPMPT	DEG_SCF_FBW7_1	0.1667
p.D27H	DO219012	BLCA	ICGC	LATPMPT	DEG_SCF_FBW7_1	0.1667
p.S45L	DO222957	BTCA	ICGC	LATPMPT	DEG_SCF_FBW7_1	0.1667
p.P38H	DO228092	EOPC	ICGC	LATPMPT	DEG_SCF_FBW7_1	0.6583
p.P36T	DO228939	LICA	ICGC	LATPMPT	DEG_SCF_FBW7_1	0.7031
p.P38T	DO229031	LICA	ICGC	LATPMPT	DEG_SCF_FBW7_1	0.5919
p.P40L	SIDM01151	Hepatocellular Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	0.3056
p.P40L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	0.3056
p.P40L	SIDM00164	Biliary Tract Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	0.3056
p.I26V	SIDM00845	Burkitt's Lymphoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	0.1389
p.I26V	SIDM01519	Head and Neck Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	0.1389
p.S41L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LATPMPT	DEG_SCF_FBW7_1	0.2778
p.S41L	ACH-000878	Lung Cancer	CCLE	LATPMPT	DEG_SCF_FBW7_1	0.2778
p.S41L	HCC-15	lung	COSMIC	LATPMPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KN83	Protein strawberry notch homolog 1	DEG_SCF_FBW7_1	33:39	LATPMPT	FBXW7	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons