DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: DEG_SCF_FBW7_1

Location: 826:833

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 79.2125

COIL: 0.9153

CONS_SCORE: 0.2835

DSS_SCORE: 0.648

HELIX: 0.0539

FCONS_SCORE: 1.0043

RIG_SCORE: 0.5637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L841F	TCGA-66-2785	LUSC	TCGA	PNSTPANS	DEG_SCF_FBW7_1	0.1111
p.L841F	DO26520	LUSC	ICGC	PNSTPANS	DEG_SCF_FBW7_1	0.1111
p.P820Q	TCGA-DA-A1I7	SKCM	TCGA	PNSTPANS	DEG_SCF_FBW7_1	0.1667
p.P820Q	DO37951	SKCM	ICGC	PNSTPANS	DEG_SCF_FBW7_1	0.1667
p.S817P	SIDM00193	Colorectal Carcinoma	GDSC	PNSTPANS	DEG_SCF_FBW7_1	0.5278
p.S817P	ACH-000991	Colon/Colorectal Cancer	CCLE	PNSTPANS	DEG_SCF_FBW7_1	0.5278
p.S817P	SNU-81	large_intestine	COSMIC	PNSTPANS	DEG_SCF_FBW7_1	0.5278
p.S816P	SNU-81	large_intestine	COSMIC	PNSTPANS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KN83	Protein strawberry notch homolog 1	DEG_SCF_FBW7_1	826:833	PNSTPANS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons