DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: LIG_APCC_ABBA_1

Location: 761:766

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 81.5

COIL: 0.7543

CONS_SCORE: 0.3666

DSS_SCORE: 0.7069

HELIX: 0.1937

FCONS_SCORE: 1.1624

RIG_SCORE: 0.6901

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P763Q	TCGA-AC-A23H	BRCA	TCGA	FNPFLD	LIG_APCC_ABBA_1	0.7035
p.P763Q	DO2401	BRCA	ICGC	FNPFLD	LIG_APCC_ABBA_1	0.7035
p.P776L	TCGA-EE-A2A2	SKCM	TCGA	FNPFLD	LIG_APCC_ABBA_1	0.0556
p.P776L	DO37583	SKCM	ICGC	FNPFLD	LIG_APCC_ABBA_1	0.0556
p.S768C	TCGA-YC-A9TC	BLCA	TCGA	FNPFLD	LIG_APCC_ABBA_1	0.7222
p.S768C	DO51949	BLCA	ICGC	FNPFLD	LIG_APCC_ABBA_1	0.7222
p.S768C	SIDM00485	Oral Cavity Carcinoma	GDSC	FNPFLD	LIG_APCC_ABBA_1	0.7222
p.S768C	ACH-000794	Head and Neck Cancer	CCLE	FNPFLD	LIG_APCC_ABBA_1	0.7222
p.S768C	BICR22	upper_aerodigestive_tract	COSMIC	FNPFLD	LIG_APCC_ABBA_1	0.7222
p.N752K	DO229027	LICA	ICGC	FNPFLD	LIG_APCC_ABBA_1	0.0833
p.N769D	SIDM00396	Acute Myeloid Leukemia	GDSC	FNPFLD	LIG_APCC_ABBA_1	0.25
p.N769D	ACH-000112	Leukemia	CCLE	FNPFLD	LIG_APCC_ABBA_1	0.25
p.N769D	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	FNPFLD	LIG_APCC_ABBA_1	0.25
p.S767C	BICR22	upper_aerodigestive_tract	COSMIC	FNPFLD	LIG_APCC_ABBA_1	0.3056
p.N768D	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	FNPFLD	LIG_APCC_ABBA_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KN83	Protein strawberry notch homolog 1	LIG_APCC_ABBA_1	761:766	FNPFLD	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons