DegronMD

Uniprot ID: A3KN83

Source protein: Protein strawberry notch homolog 1

Source gene: SBNO1

Class: DEG_APCC_KENBOX_2

Location: 699:703

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8367

ASA_SCORE: 100.38

COIL: 0.6598

CONS_SCORE: 0.2784

DSS_SCORE: 0.6608

HELIX: 0.3046

FCONS_SCORE: 0.9731

RIG_SCORE: 0.7096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S693L	TCGA-AG-A002	READ	TCGA	CKENK	DEG_APCC_KENBOX_2	0.6111
p.S693L	TCGA-E6-A1LX	UCEC	TCGA	CKENK	DEG_APCC_KENBOX_2	0.6111
p.S693L	DO41020	UCEC	ICGC	CKENK	DEG_APCC_KENBOX_2	0.6111
p.R707L	TCGA-D3-A2JP	SKCM	TCGA	CKENK	DEG_APCC_KENBOX_2	0.2222
p.R707L	DO47407	SKCM	ICGC	CKENK	DEG_APCC_KENBOX_2	0.2222
p.P698L	DO222647	MELA	ICGC	CKENK	DEG_APCC_KENBOX_2	0.3056
p.P694L	DO222653	MELA	ICGC	CKENK	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_APCC_KENBOX_2	1406:1410	CKENK	APC,CDC20,FZR1	0.5523	More...
A3KN83	Protein strawberry notch homolog 1	DEG_APCC_KENBOX_2	699:703	CKENK	APC,CDC20,FZR1	0.8367	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons