DegronMD

Uniprot ID: Q9BYP7

Source protein: Serine/threonine-protein kinase WNK3

Source gene: WNK3

Class: DEG_SCF_FBW7_2

Location: 1433:1438

E3 ligase: FBXW7

DEGRON score: 0.8861

ASA_SCORE: 105.5333

COIL: 0.8288

CONS_SCORE: 0.4095

DSS_SCORE: 0.5587

HELIX: 0.1205

FCONS_SCORE: 1.0342

RIG_SCORE: 0.7136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1427K	TCGA-A1-A0SI	BRCA	TCGA	VTPEKE	DEG_SCF_FBW7_2	0.1667
p.E1427K	DO1774	BRCA	ICGC	VTPEKE	DEG_SCF_FBW7_2	0.1667
p.E1440K	TCGA-C5-A7CJ	CESC	TCGA	VTPEKE	DEG_SCF_FBW7_2	0.2778
p.E1440K	DO49886	CESC	ICGC	VTPEKE	DEG_SCF_FBW7_2	0.2778
p.S1448R	DO229015	LICA	ICGC	VTPEKE	DEG_SCF_FBW7_2	0.0556
p.P1435S	DO231047	LUSC	ICGC	VTPEKE	DEG_SCF_FBW7_2	0.6752
p.S1443L	DO220897	MELA	ICGC	VTPEKE	DEG_SCF_FBW7_2	0.1944
p.P1435L	DO222527	MELA	ICGC	VTPEKE	DEG_SCF_FBW7_2	0.7582
p.S1423R	JHH-2	liver	COSMIC	VTPEKE	DEG_SCF_FBW7_2	0.0556
p.A1430S	NCI-H1417	lung	COSMIC	VTPEKE	DEG_SCF_FBW7_2	0.25
p.A1440V	SNU-1040	large_intestine	COSMIC	VTPEKE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SCF_FBW7_2	1433:1438	VTPEKE	FBXW7	0.8861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons