DegronMD

Uniprot ID: Q9BYP7

Source protein: Serine/threonine-protein kinase WNK3

Source gene: WNK3

Class: DEG_APCC_DBOX_1

Location: 915:923

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8998

ASA_SCORE: 94.9667

COIL: 0.7946

CONS_SCORE: 0.3867

DSS_SCORE: 0.5037

HELIX: 0.1341

FCONS_SCORE: 1.0065

RIG_SCORE: 0.7796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P906T	TCGA-21-1070	LUSC	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	0.0833
p.P906T	DO27088	LUSC	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.0833
p.I914T	TCGA-A3-A8CQ	KIRC	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	0.3056
p.I914T	DO49688	KIRC	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.3056
p.S910I	TCGA-AX-A2HC	UCEC	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	0.1944
p.S910I	DO41572	UCEC	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.1944
p.L919F	TCGA-BR-6802	STAD	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	0.6981
p.L919F	DO38332	STAD	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.6981
p.N925S	TCGA-V1-A9O5	PRAD	TCGA	SRDTLLTIE	DEG_APCC_DBOX_1	0.2778
p.N925S	DO219369	PRAD	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.2778
p.R929H	DO222955	BTCA	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.1667
p.A930V	DO222973	BTCA	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.1389
p.E913K	DO222749	MELA	ICGC	SRDTLLTIE	DEG_APCC_DBOX_1	0.2778
p.R916W	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	SRDTLLTIE	DEG_APCC_DBOX_1	0.8634
p.R916W	T-T	oesophagus	COSMIC	SRDTLLTIE	DEG_APCC_DBOX_1	0.8634
p.S905N	SIDM00841	Colorectal Carcinoma	GDSC	SRDTLLTIE	DEG_APCC_DBOX_1	0.5
p.S905N	SW620	large_intestine	COSMIC	SRDTLLTIE	DEG_APCC_DBOX_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_APCC_DBOX_1	915:923	SRDTLLTIE	APC,CDC20,FZR1	0.8998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons