DegronMD

Uniprot ID: Q9BYP7

Source protein: Serine/threonine-protein kinase WNK3

Source gene: WNK3

Class: DEG_SCF_FBW7_2

Location: 1076:1083

E3 ligase: FBXW7

DEGRON score: 0.9394

ASA_SCORE: 95.1625

COIL: 0.9695

CONS_SCORE: 0.4087

DSS_SCORE: 0.7104

HELIX: 0.0129

FCONS_SCORE: 0.9967

RIG_SCORE: 0.6596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1076L	TCGA-21-1071	LUSC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.6471
p.P1076L	DO26918	LUSC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.6471
p.Q1088P	TCGA-93-A4JQ	LUAD	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.Q1088P	DO51195	LUAD	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.Q1088K	TCGA-AG-A00C	READ	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.P1071L	TCGA-AO-A03N	BRCA	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.P1071L	DO5808	BRCA	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.P1080T	TCGA-DJ-A2QB	THCA	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.7031
p.P1080T	DO39421	THCA	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.7031
p.P1071H	TCGA-EO-A22X	UCEC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.P1071H	DO43907	UCEC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.A1068S	TCGA-EO-A3AV	UCEC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.1111
p.A1068S	DO52412	UCEC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.1111
p.Q1088E	TCGA-HD-A4C1	HNSC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.Q1088E	DO44453	HNSC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.1944
p.P1084Q	TCGA-TM-A84G	LGG	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.3056
p.P1084Q	DO50232	LGG	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.3056
p.P1084S	TCGA-VS-A9UJ	CESC	TCGA	PTQTPGLE	DEG_SCF_FBW7_2	0.3056
p.P1084S	DO219735	CESC	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.3056
p.S1070Y	DO232067	ORCA	ICGC	PTQTPGLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SCF_FBW7_2	1076:1083	PTQTPGLE	FBXW7	0.9394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons