DegronMD

Uniprot ID: Q9UQR0

Source protein: Sex comb on midleg-like protein 2

Source gene: SCML2

Class: DEG_SPOP_SBC_1

Location: 466:470

E3 ligase: SPOP

DEGRON score: 0.9364

ASA_SCORE: 52.96

COIL: 0.7438

CONS_SCORE: 0.7168

DSS_SCORE: 0.512

HELIX: 0.129

FCONS_SCORE: 1.0322

RIG_SCORE: 0.5625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R471M	TCGA-AA-3818	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	0.3056
p.R471M	DO7792	COAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.3056
p.N460H	TCGA-AX-A2HC	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1667
p.N460H	DO41572	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.H475Q	TCGA-D3-A2JE	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1944
p.H475Q	DO219476	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1944
p.S470F	TCGA-W3-AA1V	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S470F	DO51276	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.G472D	DO233652	GACA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.L461V	DO228394	MALY	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1944
p.H480N	DO50705	ORCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0556
p.G472V	DO229208	THCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.S464C	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.S464C	ACH-000697	Lymphoma	CCLE	PFSSS	DEG_SPOP_SBC_1	0.2778
p.S464C	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.S469Y	SIDM00118	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.712
p.S469Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.712
p.S469Y	HCC2998	large_intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.712
p.S468I	ACH-000455	Brain Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	78:82	PFSSS	SPOP	0.9307	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	941:945	PFSSS	SPOP	0.9991	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	527:531	PFSSS	SPOP	0.7804	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	466:470	PFSSS	SPOP	0.9364	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1803:1807	PFSSS	SPOP	0.6327	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with SCML2 mutations

All proteins holding degron of PFSSS