DegronMD - O43294(TGFB1I1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A76S	TCGA-05-4396	LUAD	TCGA	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.P78S	TCGA-2W-A8YY	CESC	TCGA	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.6752
p.P183L	TCGA-38-4625	LUAD	TCGA	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.3056
p.S80F	TCGA-60-2720	LUSC	TCGA	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7982
p.E30K	TCGA-86-A4JF	LUAD	TCGA	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.3056
p.E30K	TCGA-86-A4JF	LUAD	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1944
p.R27H	TCGA-A5-A0G2	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.2222
p.R27H	TCGA-A5-A0G2	UCEC	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1111
p.G84S	TCGA-A6-6781	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.G84S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.G84S	ACH-000938	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.G84S	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.R27C	TCGA-B5-A11G	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.2222
p.R27C	TCGA-B5-A11G	UCEC	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1111
p.S21P	TCGA-B5-A1MR	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.0556
p.E30G	TCGA-B5-A3FA	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.3056
p.E30G	TCGA-B5-A3FA	UCEC	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1944
p.G89R	TCGA-CG-5728	STAD	TCGA	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1389
p.S83R	TCGA-CK-5916	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.3056
p.S186R	TCGA-DD-AADQ	LIHC	TCGA	VVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7427
p.P195T	TCGA-EE-A2GO	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.P34S	TCGA-EE-A3AG	SKCM	TCGA	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation altering degron motif	0.6752
p.P35L	TCGA-QB-AA9O	SKCM	TCGA	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation altering degron motif	0.6471
p.P35L	TCGA-QB-AA9O	SKCM	TCGA	PPSY	ITCH	35:38	Mutation altering degron motif	0.7582
p.T45M	DO9956	COAD	ICGC	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.1111
p.T45M	DO9956	COAD	ICGC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1389
p.T45M	SNU-C2B	large intestine	COSMIC	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.1111
p.T45M	SNU-C2B	large intestine	COSMIC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1389
p.A85S	DO233232	GACA	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.25
p.R78Q	DO233634	GACA	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7329
p.S36A	DO233869	GACA	ICGC	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation altering degron motif	0.7588
p.S36A	DO233869	GACA	ICGC	PPSY	ITCH	35:38	Mutation altering degron motif	0.7588
p.E75A	DO233911	GACA	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.25
p.D197N	DO10880	GBM	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.G183V	DO228948	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.3056
p.G183V	DO228985	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.3056
p.G70V	DO229029	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation substituting flanking lysine	0.2222
p.T45K	DO24527	LUAD	ICGC	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.1111
p.T45K	DO24527	LUAD	ICGC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1389
p.D38N	DO25426	LUAD	ICGC	PPSY	ITCH	35:38	Mutation altering degron motif	0.6932
p.G174A	DO231179	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.Q195H	DO26934	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.S186T	DO219182	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6005
p.P25S	DO228429	MALY	ICGC	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation substituting flanking lysine	0.2778
p.P25S	DO228429	MALY	ICGC	PPSY	ITCH	35:38	Mutation substituting flanking lysine	0.1667
p.S196F	DO46478	OV	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.G185D	DO36293	PRAD	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7198
p.G185D	DO38404	STAD	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7198
p.H23P	DO229499	SKCA	ICGC	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.1111
p.D92A	DO229446	SKCA	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0556
p.P178T	DO37823	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.G72R	DO38619	STAD	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.L80F	DO43041	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.6981
p.A35V	DO41235	UCEC	ICGC	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation altering degron motif	0.6936
p.A35V	DO41235	UCEC	ICGC	PPSY	ITCH	35:38	Mutation altering degron motif	0.6936
p.R78W	DO41133	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.8634
p.A72S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.A72S	ACH-000960	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.A72S	REH	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.P77H	SIDM00596	Endometrial Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.3056
p.P77H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.3056
p.P77H	HEC-1	endometrium	COSMIC	PFSSS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.3056
p.T33P	ACH-000067	Brain Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	31:37	Mutation altering degron motif	0.8142

Kaplan plot for TGFB1I1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGFB1I1

UniProt ID: O43294

Entrez ID: 7041

Protein name: Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGFB1I1 in