DegronMD

Uniprot ID: O43294

Source protein: Transforming growth factor beta-1-induced transcript 1 protein

Source gene: TGFB1I1

Class: DEG_SPOP_SBC_1

Location: 184:188

E3 ligase: SPOP

DEGRON score: 0.9948

ASA_SCORE: 85.88

COIL: 0.9182

CONS_SCORE: 0.4095

DSS_SCORE: 0.8257

HELIX: 0.0304

FCONS_SCORE: 1.0476

RIG_SCORE: 0.584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P183L	TCGA-38-4625	LUAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.3056
p.S186R	TCGA-DD-AADQ	LIHC	TCGA	VVSST	DEG_SPOP_SBC_1	0.7427
p.P195T	TCGA-EE-A2GO	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	0.1389
p.D197N	DO10880	GBM	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.G183V	DO228948	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.G183V	DO228985	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.G174A	DO231179	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.Q195H	DO26934	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.S186T	DO219182	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.6005
p.S196F	DO46478	OV	ICGC	VVSST	DEG_SPOP_SBC_1	0.1111
p.G185D	DO36293	PRAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.7198
p.G185D	DO38404	STAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.7198
p.P178T	DO37823	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons