DegronMD

Uniprot ID: Q9HCP0

Source protein: Casein kinase I isoform gamma-1

Source gene: CSNK1G1

Class: DEG_SPOP_SBC_1

Location: 370:374

E3 ligase: SPOP

DEGRON score: 0.9967

ASA_SCORE: 81.08

COIL: 0.8318

CONS_SCORE: 0.3879

DSS_SCORE: 0.715

HELIX: 0.051

FCONS_SCORE: 1.0913

RIG_SCORE: 0.654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q369E	TCGA-CQ-6221	HNSC	TCGA	VVSST	DEG_SPOP_SBC_1	0.3056
p.Q369E	DO14622	HNSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.Q369H	TCGA-D3-A1Q3	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	0.3056
p.Q369H	DO47509	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.R367Q	TCGA-G4-6306	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.25
p.R367Q	DO8055	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.V371I	DO52518	EOPC	ICGC	VVSST	DEG_SPOP_SBC_1	0.5965
p.T384K	DO229026	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.T384M	DO229053	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.T384M	DO27827	MALY	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.N383K	DO229006	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.S372I	DO36881	READ	ICGC	VVSST	DEG_SPOP_SBC_1	0.7341
p.N379D	DO229250	THCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons