DegronMD - Q9HCP0(CSNK1G1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q369E	TCGA-CQ-6221	HNSC	TCGA	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.3056
p.Q369E	DO14622	HNSC	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.3056
p.Q369H	TCGA-D3-A1Q3	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.3056
p.Q369H	DO47509	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.3056
p.G338V	TCGA-FS-A1ZN	SKCM	TCGA	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation altering degron motif	0.6421
p.G338V	DO38165	SKCM	ICGC	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation altering degron motif	0.6421
p.R367Q	TCGA-G4-6306	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.25
p.R367Q	DO8055	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.25
p.T335S	TCGA-XF-AAN1	BLCA	TCGA	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation altering degron motif	0.7116
p.T335S	DO51942	BLCA	ICGC	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation altering degron motif	0.7116
p.V371I	DO52518	EOPC	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.5965
p.V329I	DO222758	ESCA	ICGC	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation rewiring degron network	0.25
p.T384K	DO229026	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.T384M	DO229053	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.T384M	DO27827	MALY	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.N383K	DO229006	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0833
p.S372I	DO36881	READ	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.7341
p.N379D	DO229250	THCA	ICGC	VVSST	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1944
p.Y324H	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation rewiring degron network	0.1111
p.Y324H	ACH-000326	Leukemia	CCLE	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation rewiring degron network	0.1111
p.Y324H	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation rewiring degron network	0.1111
p.P336Q	ACH-000961	Endometrial/Uterine Cancer	CCLE	PIPTPVGS	DEG_SCF_FBW7_1	332:339	Mutation altering degron motif	0.7035

Kaplan plot for CSNK1G1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSNK1G1

UniProt ID: Q9HCP0

Entrez ID: 53944

Protein name: Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSNK1G1 in