DegronMD

Uniprot ID: Q9HCP0

Source protein: Casein kinase I isoform gamma-1

Source gene: CSNK1G1

Class: DEG_SCF_FBW7_1

Location: 332:339

E3 ligase: FBXW7

DEGRON score: 0.9951

ASA_SCORE: 84.8375

COIL: 0.96

CONS_SCORE: 0.3639

DSS_SCORE: 0.3258

HELIX: 0.0146

FCONS_SCORE: 0.8521

RIG_SCORE: 0.7256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G338V	TCGA-FS-A1ZN	SKCM	TCGA	PIPTPVGS	DEG_SCF_FBW7_1	0.6421
p.G338V	DO38165	SKCM	ICGC	PIPTPVGS	DEG_SCF_FBW7_1	0.6421
p.T335S	TCGA-XF-AAN1	BLCA	TCGA	PIPTPVGS	DEG_SCF_FBW7_1	0.7116
p.T335S	DO51942	BLCA	ICGC	PIPTPVGS	DEG_SCF_FBW7_1	0.7116
p.V329I	DO222758	ESCA	ICGC	PIPTPVGS	DEG_SCF_FBW7_1	0.25
p.Y324H	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PIPTPVGS	DEG_SCF_FBW7_1	0.1111
p.Y324H	ACH-000326	Leukemia	CCLE	PIPTPVGS	DEG_SCF_FBW7_1	0.1111
p.Y324H	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PIPTPVGS	DEG_SCF_FBW7_1	0.1111
p.P336Q	ACH-000961	Endometrial/Uterine Cancer	CCLE	PIPTPVGS	DEG_SCF_FBW7_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SCF_FBW7_1	332:339	PIPTPVGS	FBXW7	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons