DegronMD - P21583(KITLG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A157T	TCGA-AA-A00N	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.A157T	DO9876	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.V165F	TCGA-BS-A0UA	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.5957
p.V165F	DO42552	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.5957
p.P171S	TCGA-C8-A12O	BRCA	TCGA	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.P171S	DO4677	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.S167L	TCGA-EE-A2GC	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7667
p.S167L	DO37839	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7667
p.R176T	TCGA-G2-AA3C	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.R176T	DO51883	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.T168K	DO229019	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7306
p.P171H	DO219878	SKCA	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.V155A	DO229213	THCA	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.K177N	DO41133	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.S175Y	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.F154L	SIDM00503	Gastric Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.F154L	ACH-000633	Gastric Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.F154L	FU97	stomach	COSMIC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.V164A	SIDM00980	Gastric Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.5825
p.V164A	23132-87	stomach	COSMIC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.5825
p.A176G	ES6	bone	COSMIC	VVSST	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111

Kaplan plot for KITLG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KITLG

UniProt ID: P21583

Entrez ID: 4254

Protein name: Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KITLG in