DegronMD

Uniprot ID: P21583

Source protein: Kit ligand

Source gene: KITLG

Class: DEG_SPOP_SBC_1

Location: 164:168

E3 ligase: SPOP

DEGRON score: 0.9767

ASA_SCORE: 67.48

COIL: 0.8562

CONS_SCORE: 0.5509

DSS_SCORE: 0.3461

HELIX: 0.039

FCONS_SCORE: 1.0805

RIG_SCORE: 0.7753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A157T	TCGA-AA-A00N	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.1389
p.A157T	DO9876	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.V165F	TCGA-BS-A0UA	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.5957
p.V165F	DO42552	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.5957
p.P171S	TCGA-C8-A12O	BRCA	TCGA	VVSST	DEG_SPOP_SBC_1	0.25
p.P171S	DO4677	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.S167L	TCGA-EE-A2GC	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	0.7667
p.S167L	DO37839	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.7667
p.R176T	TCGA-G2-AA3C	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	0.1111
p.R176T	DO51883	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1111
p.T168K	DO229019	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.7306
p.P171H	DO219878	SKCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.V155A	DO229213	THCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.K177N	DO41133	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.S175Y	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.1389
p.F154L	SIDM00503	Gastric Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.0556
p.F154L	ACH-000633	Gastric Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.0556
p.F154L	FU97	stomach	COSMIC	VVSST	DEG_SPOP_SBC_1	0.0556
p.V164A	SIDM00980	Gastric Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.5825
p.V164A	23132-87	stomach	COSMIC	VVSST	DEG_SPOP_SBC_1	0.5825
p.A176G	ES6	bone	COSMIC	VVSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons