DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VVSST
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
1337:1341
E3 ligase:
SPOP
DEGRON score:
0.7602
ASA_SCORE:
72.44
COIL:
0.6282
CONS_SCORE:
0.3266
DSS_SCORE:
0.5487
HELIX:
0.0342
FCONS_SCORE:
0.8313
RIG_SCORE:
0.6609
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VVSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43294
Transforming growth factor beta-1-induced transcript 1 protein
DEG_SPOP_SBC_1
184:188
VVSST
SPOP
0.9948
More...
P16144
Integrin beta-4
DEG_SPOP_SBC_1
1230:1234
VVSST
SPOP
0.5329
More...
P21583
Kit ligand
DEG_SPOP_SBC_1
164:168
VVSST
SPOP
0.9767
More...
P51003
Poly
DEG_SPOP_SBC_1
615:619
VVSST
SPOP
0.7739
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
1337:1341
VVSST
SPOP
0.7602
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
1739:1743
VVSST
SPOP
0.9233
More...
Q14241
Elongin-A
DEG_SPOP_SBC_1
763:767
VVSST
SPOP
0.7077
More...
Q8N573
Oxidation resistance protein 1
DEG_SPOP_SBC_1
199:203
VVSST
SPOP
0.9992
More...
Q96B97
SH3 domain-containing kinase-binding protein 1
DEG_SPOP_SBC_1
469:473
VVSST
SPOP
0.9973
More...
Q9BXR0
Queuine tRNA-ribosyltransferase catalytic subunit 1
DEG_SPOP_SBC_1
161:165
VVSST
SPOP
0.5555
More...
Q9HCP0
Casein kinase I isoform gamma-1
DEG_SPOP_SBC_1
370:374
VVSST
SPOP
0.9967
More...
Q9NYB9
Abl interactor 2
DEG_SPOP_SBC_1
337:341
VVSST
SPOP
0.9646
More...
Q9Y6M4
Casein kinase I isoform gamma-3
DEG_SPOP_SBC_1
395:399
VVSST
SPOP
0.9966
More...
Q9NRJ5
Poly
DEG_SPOP_SBC_1
614:618
VVSST
SPOP
0.8298
More...
Q8NEM2
SHC SH2 domain-binding protein 1
DEG_SPOP_SBC_1
334:338
VVSST
SPOP
0.5138
More...